GRF11 Antibody
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Description
Iron Deficiency Response
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GRF11 is essential for activating Fe-deficiency tolerance mechanisms. Loss-of-function grf11 mutants exhibit impaired Fe homeostasis .
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Mechanism:
Protein Interaction Studies
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The antibody detects GRF11 in Western blot assays across plant species, including Lilium longiflorum and Chlamydomonas reinhardtii .
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Immunoprecipitation (IP) confirmed its ability to isolate GRF11 from plant cell lysates .
Comparative Analysis of 14-3-3 GRF Isoforms
GRF11 is one of 12 canonical 14-3-3 isoforms in Arabidopsis. The table below highlights key isoforms detected by the antibody:
| Isoform | UniProt ID | TAIR Code | Role |
|---|---|---|---|
| GRF1 | F4JJ94 | AT4G09000 | Stress signaling |
| GRF2 | Q01525 | AT1G78300 | Metabolic regulation |
| GRF11 | Q9S9Z8 | AT1G34760 | Fe-deficiency response |
| GRF6 | P48349 | AT5G10450 | Pathogen defense |
Future Directions
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Agricultural Biotechnology: Engineering GRF11 overexpression to enhance crop resilience under nutrient-poor soils.
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Clinical Relevance: Exploring homologs in mammals for potential therapeutic applications in metal metabolism disorders.
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
GRF11 antibody; At1g34760 antibody; F21H2.314-3-3-like protein GF14 omicron antibody; General regulatory factor 11 antibody
Target Names
GRF11
Uniprot No.
Target Background
Function
GRF11 Antibody is associated with a DNA binding complex that interacts with the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
Gene References Into Functions
- GRF11 plays a crucial role in mediating iron deficiency responses. Upon the onset of iron deficiency, the expression of the FIT gene is induced, and this induction is dependent on GRF11 acting downstream of nitric oxide (NO). PMID: 23252371
Database Links
Protein Families
14-3-3 family
Subcellular Location
Nucleus. Cytoplasm.
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