B'GAMMA Antibody

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Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
B'GAMMA antibody; At4g15415 antibody; dl3750w antibody; FCAALL.118Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform antibody; AtB' gamma antibody; PP2A antibody; B' subunit antibody; gamma isoform antibody
Target Names
B'GAMMA
Uniprot No.

Target Background

Function
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. It is essential for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signaling by dephosphorylating and inactivating BRI1 in the cytoplasm. This subunit appears to be functionally connected with CPR5 and may mediate the negative regulation of defense reactions and senescence under low irradiances. It may contribute to the epigenetic regulation of defense gene expression. It is involved in the control of methoxylation of indole glucosinolates and formation of 4-methoxy- indol-3-yl-methyl glucosinolate in leaves, through direct interaction with indole glucosinolate methyltransferases. This subunit participates in growth regulation and stress signaling. It is involved in the regulation of reactive oxygen species (ROS) signaling and maintenance of cellular ROS homeostasis. It is required to control the level of ACO3 phosphorylation in the cytoplasm. It regulates hydrogen peroxide metabolism by controlling the abundance of AOX1A and AXO3/AOX1D in leaf mitochondria. This subunit may mediate dephosphorylation of CRT1 and promote the degradation of unfolded proteins in endoplasmic reticulum (ER). It is involved in the regulation of flowering time by repressing FLC, the main flowering repressor gene.
Gene References Into Functions
  1. Research indicates that the cytoplasmic protein phosphatase 2A regulatory subunit B'gamma (PP2A-B'gamma) is essential for controlling the amount of a specifically methoxylated indole glucosinolate 4MO-I3M. PMID: 27598402
  2. PP2A-B'gamma interacts physically with the cytoplasmic form of aconitase and influences reactive oxygen species homeostasis by regulating the abundance of specific alternative oxidase isoforms, AOX1A and AOX1D, in leaf mitochondria. PMID: 25307043
  3. PP2A-B'gamma is a positive regulator of flowering, contributing to the repression of the major flowering repressor gene FLC in Arabidopsis. PMID: 23976921
  4. The specific B'gamma subunit of PP2A modulates the extent of ER-stress through dephosphorylation of CALRETICULIN 1. PMID: 22041935
  5. The specific B'gamma subunit of PP2A is functionally connected to CPR5 and participates in the basal repression of defense responses under low irradiance. PMID: 21571669

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Database Links

KEGG: ath:AT4G15415

STRING: 3702.AT4G15415.1

UniGene: At.4343

Protein Families
Phosphatase 2A regulatory subunit B56 family
Subcellular Location
Cytoplasm, cytosol. Nucleus.
Tissue Specificity
Expressed ubiquitously at low levels. Expressed in roots, emerging lateral roots, cotyledons, leaves, floral stalks and flowers.

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