Function
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. It is essential for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signaling by dephosphorylating and inactivating BRI1 in the cytoplasm. This subunit appears to be functionally connected with CPR5 and may mediate the negative regulation of defense reactions and senescence under low irradiances. It may contribute to the epigenetic regulation of defense gene expression. It is involved in the control of methoxylation of indole glucosinolates and formation of 4-methoxy- indol-3-yl-methyl glucosinolate in leaves, through direct interaction with indole glucosinolate methyltransferases. This subunit participates in growth regulation and stress signaling. It is involved in the regulation of reactive oxygen species (ROS) signaling and maintenance of cellular ROS homeostasis. It is required to control the level of ACO3 phosphorylation in the cytoplasm. It regulates hydrogen peroxide metabolism by controlling the abundance of AOX1A and AXO3/AOX1D in leaf mitochondria. This subunit may mediate dephosphorylation of CRT1 and promote the degradation of unfolded proteins in endoplasmic reticulum (ER). It is involved in the regulation of flowering time by repressing FLC, the main flowering repressor gene.