5MMP Antibody

MMP-24/MT5-MMP: Biological Function and Significance

MMP-24 belongs to the matrix metalloproteinase family, zinc-dependent proteases involved in extracellular matrix (ECM) remodeling. Key characteristics include:

• Structural domains: Pro-peptide, catalytic, hinge, and hemopexin-like regions .

• Role: Cleaves ECM components (e.g., collagen, laminin) and regulates cytokines, growth factors, and cell adhesion molecules .

• Disease association: Overexpression observed in gliomas, astrocytomas, and other cancers, correlating with tumor invasiveness .

AB924: Anti-MMP-24/MT5-MMP Antibody

The AB924 antibody (R&D Systems® Catalog # AB924) is a rabbit polyclonal antibody validated for immunohistochemistry (IHC) in human and mouse tissues.

Key Research Applications

Neuropathology Studies

• Normal brain tissue: MMP-24 localized to neuronal cytoplasm, suggesting roles in synaptic plasticity .

• Astrocytoma: Strong cytoplasmic staining in tumor cells, implicating MMP-24 in glioma progression .

Comparative Analysis

AB924’s specificity for MMP-24 distinguishes it from antibodies targeting other MMPs (e.g., MMP-9, MMP-14). Unlike broad-spectrum MMP inhibitors, AB924 enables precise mechanistic studies of MMP-24 in neurological and oncological contexts .

Clinical and Therapeutic Context

While AB924 is primarily a research tool, monoclonal antibodies (mAbs) broadly have transformed medicine:

• Cancer: 37% of FDA-approved mAbs target oncology indications (e.g., trastuzumab, rituximab) .

• Infectious diseases: mAbs like SC27 show pan-coronavirus neutralization, including SARS-CoV-2 variants .

• Autoimmunity: Anti-laminin 5 antibodies aid in diagnosing mucous membrane pemphigoid .

Limitations and Future Directions

• AB924 limitations: No therapeutic use reported; confined to preclinical IHC .

• Therapeutic potential: Engineered mAbs targeting MMP-24 could inhibit metastasis or modulate ECM in fibrosis, but require clinical validation .