atg-16.2 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
atg-16.2 antibody; K06A1.5Autophagic-related protein 16.2 antibody
Target Names
atg-16.2
Uniprot No.
Target Background
Function
ATG-16.2 is likely a component of the ATG-5-ATG-12-ATG-16.1/ATG-16.2 complex, which is recruited to the preautophagosomal membrane and interacts with LGG-2 to facilitate autophagosome formation. It plays a role in recruiting lipidated LGG-1, likely to the autophagosome membrane, to further promote autophagosome formation. Furthermore, its association with ATG-5 is essential for the nucleation of LGG-1 positive autophagosomes. Although its role in autophagosome formation may differ from that of ATG-16.2, it functions partially redundantly with ATG-16.1 to regulate autophagic processes. In a DAF-18/PTEN- and DAF-16/FOXO-dependent manner, ATG-16.2 is required for maintaining the number of germ stem cell progenitors in the gonad during the later stages of larval development.
Gene References Into Functions
- C. elegans ATG-16 proteins are involved in specifying LGG-1 puncta formation; the two ATG-16 homologs exhibit partially redundant yet distinct functions in the aggrephagy pathway. PMID: 24185444
Database Links
Protein Families
WD repeat tipD family
Subcellular Location
Cytoplasm. Cell membrane.
Tissue Specificity
Expressed in neurons, pharyngeal muscles, body wall muscle cells and intestinal cells.
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