AAP4 Antibody
Description
Clarification of Terminology
The term "AAP4 Antibody" does not match any antibodies documented in the provided sources. Possible corrections or related compounds include:
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APP A4 Antibody: Targets the amyloid precursor protein (APP) and is associated with Alzheimer’s disease research.
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Anti-PAD4 (aPAD4): Targets peptidyl-arginine deiminase 4 (PAD4) and is studied in rheumatoid arthritis.
APP A4 Antibody (Amyloid Precursor Protein A4)
APP A4 antibodies target the N-terminal region of APP, a protein implicated in Alzheimer’s disease.
Key Features
Research Findings
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Diagnostic Utility: APP A4 antibodies help distinguish APP from amyloid-β (Aβ) plaques, as they recognize the extracellular domain of APP outside the Aβ region .
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Cross-Reactivity: Some APP antibodies (e.g., 4G8) may bind N-truncated Aβ fragments, complicating specificity .
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Experimental Models: APP A4 antibodies are used to study APP processing and neuroinflammation in Alzheimer’s models .
Anti-PAD4 (aPAD4) Antibodies
aPAD4 antibodies target peptidyl-arginine deiminase 4 (PAD4), an enzyme that converts arginine to citrulline, a process linked to autoantigen formation in rheumatoid arthritis (RA).
Key Features
Research Findings
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Treatment Prediction: aPAD4 positivity, alone or combined with ACPA, enhances prediction of abatacept (ABT) response in RA. Double-negative patients (ACPA-/aPAD4-) show reduced EULAR response rates (46.4% vs. 88.9% in aPAD4+ patients) .
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Drug Retention: Patients positive for aPAD4, ACPA, or aCarP (carbamylated protein antibodies) exhibit higher 3-year ABT retention rates .
APOE Antibodies (e.g., HAE-4)
APOE antibodies target apolipoprotein E, a protein linked to amyloid-β (Aβ) pathology in Alzheimer’s disease.
Key Features
| Parameter | Details |
|---|---|
| Target | Human APOE4, co-deposited with Aβ in cerebral amyloid angiopathy (CAA) |
| Therapeutic Use | Reduces Aβ plaques and CAA in transgenic mice without exacerbating microhemorrhages |
AQP4 Antibodies
AQP4 antibodies target aquaporin-4, a water channel protein implicated in neuromyelitis optica spectrum disorder (NMOSD).
Key Features
Antibody Detection Methods
Advanced techniques like Agglutination-PCR (ADAP) enable ultrasensitive antibody detection (zepto- to attomolar levels), addressing limitations of solid-phase assays .
Product Specs
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
