aak-2 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
aak-2 antibody; T01C8.15'-AMP-activated protein kinase catalytic subunit alpha-2 antibody; AMPK subunit alpha-2 antibody; EC 2.7.11.1 antibody
Target Names
aak-2
Uniprot No.
Target Background
Function
AAK-2, the AMP-activated protein kinase catalytic subunit, plays a multifaceted role in Caenorhabditis elegans. It functions as a sensor that links lifespan to energy levels and insulin-like signals. Furthermore, it influences motility, response to oxidative stress, germline stem cell quiescence during dauer development, axon regrowth following nerve injury, glycogen maintenance for hyperosmotic stress resistance, and the regulation of flp-7 secretion from ASI neurons. This protein also keeps the CREB-regulated transcription coactivator 1 homolog (crtc-1) inactive, thereby inhibiting flp-7 secretion. Upon serotonin signaling, AAK-2 derepresses crtc-1, which stimulates flp-7 secretion and subsequent body fat loss.
Gene References Into Functions
Function and References
- Reducing Indy/CeNAC2 expression, a homolog of the human nicotinamide nucleotide transhydrogenase, extends lifespan by 22+/-3 % compared to control organisms. This reduction also decreases whole body fat content by ~50% and increases the activation of the intracellular energy sensor AMPK/aak2. PMID: 26318988
- Inactivating AAK-2 in ASI neurons, similar to elevated serotonin signaling, leads to enhanced secretion of dense core vesicles from these neurons. PMID: 24921650
- The metabolic sensor AMP kinase, AAK-2, is a crucial output of RSKS-1 in axon regrowth. PMID: 24431434
- AMPK catalytic subunit aak-2 mutants exhibit elevated pharyngeal pumping even in the absence of exogenous 5-HT. PMID: 22768843
- An animal's ability to survive extended periods of severe oxygen deprivation is likely dependent on specific subunits of the heterotrimeric protein AMPK and energy stores such as carbohydrates. PMID: 21304820
- These findings demonstrate that aging is governed by overlapping yet distinct pathways, and that AMPK/aak-2 serves as a central component within a network of evolutionarily conserved biochemical pathways that regulate aging. PMID: 16626391
- C. elegans larvae lacking LKB1/AMPK (AMP-activated protein kinase) signaling enter dauer normally but subsequently consume their stored energy rapidly, leading to premature death due to vital organ failure. PMID: 19052547
- aak-2 is essential for lifespan extension in conditions of impaired glycolysis and calorie restriction. It initiates increased mitochondrial respiration and heightened oxidative stress/ROS formation, promoting mitohormesis. PMID: 17908557
Database Links
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Tissue Specificity
Expressed in the pharynx, the ventral cord, neurons including the hermaphrodite-specific neuron, body wall muscles, the vulva, the excretory canal, and weakly in the intestine.
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