ASP1 Antibody

rOv-ASP-1: A Helminth-Derived Immunostimulatory Adjuvant

The recombinant Onchocerca volvulus activation-associated secreted protein-1 (rOv-ASP-1) is a potent adjuvant that enhances vaccine efficacy through antigen-sparing and cross-reactive immunity.

Key Research Findings:

• Antigen-Sparing Effect:
  rOv-ASP-1 allows a 10-fold reduction in influenza vaccine dose while maintaining robust antibody responses. For example, mice immunized with 0.3 μg TIV (trivalent influenza vaccine) + 20 μg rOv-ASP-1 showed IgG levels comparable to 3 μg TIV alone .

• Th1-Biased Immunity:
  Co-administration with TIV induced Th1-associated IgG2c antibodies, unlike alum-based adjuvants .

• Cross-Reactive Protection:
  Enhanced cross-reactive IgG against antigenically distinct influenza strains (e.g., PR8 H1N1) was observed post-boost, with >10-fold higher titers compared to TIV alone .

Table 1: rOv-ASP-1 Adjuvant Properties

ASP-1 Monoclonal Antibody for ABH Blood Group Antigens

ASP-1 is a murine monoclonal antibody specific to high-molecular-weight (>200 kDa) amniotic fluid proteins carrying ABH blood group antigens.

Applications and Specificity:

• Diagnostic Utility:
  Detects amniotic fluid contamination in mixed body fluids (e.g., blood, urine) at concentrations as low as 1% .

• Exclusivity:
  No cross-reactivity with semen, saliva, or vaginal secretions .

Table 2: ASP-1 Antibody Performance

ASS1 Antibody (Argininosuccinate Synthase 1)

ASS1 antibodies target the urea cycle enzyme linked to citrullinemia type I, a metabolic disorder.

Characteristics:

• Clinical Relevance:
  Mutations in ASS1 (e.g., p.G390R) are associated with classical citrullinemia .

• Technical Specifications:

  • Host: Mouse (Clone 2B10) or Rabbit

  • Applications: Western blot (WB), ELISA, Flow Cytometry (FACS) .

Table 3: ASS1 Antibody Details

Antibodies Targeting Aβ Asp1 Epimers in Alzheimer’s Disease

ASP1-modified amyloid-beta (Aβ) peptides are implicated in Alzheimer’s pathology, with antibodies like 6E10 and 4G8 showing altered binding to iso-Asp variants .

Key Insights:

• Pathological Prevalence:
  20% of Aβ Asp1 residues are iso-Asp in AD brains vs. 6% in non-AD samples .

• Therapeutic Implications:
  Epimer-specific antibodies may improve diagnostic accuracy and immunotherapy targeting .

ASPSCR1 Antibodies in Cancer Research

ASPSCR1 (alveolar soft part sarcoma chromosomal region candidate 1) antibodies are used to study translocation-driven cancers.

Key Features:

• Clone Variants:

  • M01 (3D10-1D11): Mouse monoclonal for WB/IHC .

  • HPA026749: Rabbit polyclonal for immunofluorescence .

• Applications:
  Detects ASPSCR1-TFE3 fusion proteins in alveolar soft part sarcomas .