The term "ABCI12" does not correspond to:
Standard antibody nomenclature (e.g., WHO’s INN system for monoclonal antibodies)
Gene symbols (e.g., ABCA1, ABCC12, or ABCG2 in the ATP-binding cassette transporter family)
Clinical trial identifiers (e.g., ABC-12 refers to a biliary cancer study )
Typographical error for ABCC12 (a multidrug resistance-associated protein).
Misinterpretation of ABC-12, a clinical trial identifier.
To resolve ambiguity, consider:
Verify nomenclature with the Human Genome Organisation (HUGO) Gene Nomenclature Committee.
Consult patent databases (e.g., USPTO, WIPO) for unpublished antibody designs.
Review antibody engineering platforms (e.g., yeast/bacterial display libraries in ).
If "ABCI12" refers to a novel antibody, its characterization should include:
When developing FAQs for the ABCI12 antibody in academic research, key considerations include validation protocols, experimental design robustness, and addressing reproducibility challenges. Below is a structured guide based on current best practices in antibody research and characterization.
Implement a three-tier validation framework:
Use phylogenetic alignment tools to assess epitope conservation
Test cross-reactivity in:
Validate through independent application correlation (e.g., compare IHC results with mRNA FISH data)
7. Standardized characterization workflow for new ABCI12 applications:
Pre-validation:
Experimental validation:
Documentation:
8. Addressing target polymorphism effects on antibody binding: