ABCG17 Antibody

Context of ABCG17 in Current Research

ABCG17 is a plant-specific adenosine triphosphate–binding cassette (ABC) transporter protein identified in Arabidopsis thaliana. It regulates abscisic acid (ABA) homeostasis by importing ABA into shoot parenchyma cells, influencing stomatal conductance and root development under stress conditions . No studies mention the development or use of an antibody targeting ABCG17.

2.1. Key Findings on ABCG17

• Function: ABCG17 and its homolog ABCG18 redundantly mediate ABA import into mesophyll cells, creating inactive ABA sinks to modulate stress responses .

• Localization: Plasma membrane–localized in leaf and stem parenchyma cells .

• Genetic Studies: Double-knockdown mutants (mir17,18) exhibit elevated ABA levels, reduced stomatal aperture, and impaired lateral root development .

2.2. Absence of Antibody-Specific Data

• No publications, commercial catalogs, or reagent databases (e.g., CiteAb, Antibodypedia) list an antibody targeting ABCG17.

• The provided search results focus on ABCG17's role in ABA transport and do not describe antibody development or applications .

3.1. Research Focus

• ABCG17 is primarily studied in plant biology for its role in ABA signaling, with limited translational research into antibody development.

• Antibodies are typically generated for clinical or model-organism targets (e.g., human proteins), whereas ABCG17 is plant-specific.

3.2. Nomenclature Confusion

• IL-17A Antibody (ab79056): A commercially available antibody for interleukin-17A (IL-17A) , unrelated to ABCG17.

• ABCG Family Proteins: ABCG1, ABCG2, ABCG5, and ABCG8 are well-characterized in mammals (e.g., cholesterol transport, drug resistance) , but no overlap with ABCG17.

Recommendations for Further Investigation

• Antibody Generation: Collaborate with plant biology research groups to develop custom polyclonal/monoclonal antibodies against ABCG17 epitopes.

• Functional Studies: Use CRISPR-Cas9 or RNAi techniques to explore ABCG17’s role in ABA signaling, bypassing antibody-dependent methods.