ABCG40 Antibody
Description
ABCG40 Antibody: Applications and Validation
Antibodies targeting ABCG transporters are critical for functional studies. While ABCG40-specific antibodies are not explicitly detailed, analogous antibodies (e.g., anti-ABCG2, anti-ABCG25) provide a framework:
Table 1: Key Antibody Applications for ABCG Transporters
Functional Data
-
ATPase activity: ABCG transporters exhibit intrinsic ATP hydrolysis. For example, ABCC4 shows higher ATPase activity than CFTR, with mutations (e.g., Q413A) impairing function .
-
Pathological relevance: ABCG2 overexpression correlates with chemoresistance in cancer, while ABCG25 mutations disrupt ABA signaling in plants .
Antibody Development Challenges
-
Epitope specificity: Antibodies must distinguish between homologous ABCG members (e.g., ABCG40 vs. ABCG30/31) .
-
Validation criteria: Include knockout controls, cross-reactivity screens, and functional assays (e.g., transport inhibition) .
Future Directions
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- ABCG40 imports abscisic acid into the embryo, regulating seed germination. PMID: 26334616
- Data suggest that Sorghum SbLRR2(Sb05g018800) appears to mediate Pb(II) tolerance through the elevation of AtPDR12 expression in transgenic Arabidopsis, thus activating a glutathione-independent mechanism for detoxification. PMID: 23877877
- This research identifies the ATP-binding cassette (ABC) transporter Pleiotropic drug resistance transporter PDR12 (AtPDR12)/ABCG40 as a plasma membrane abscisic acid uptake transporter. PMID: 20133880
- PDR12 is an ABC transporter that contributes to lead resistance in Arabidopsis. PMID: 15923333
