ABTB1 Antibody

Introduction to ABTB1 Antibody

The ABTB1 antibody is a research tool designed to detect Ankyrin Repeat and BTB/POZ Domain-Containing Protein 1 (ABTB1), a protein encoded by the human gene ABTB1. This protein contains structural motifs—ankyrin repeats and BTB/POZ domains—that facilitate protein-protein interactions. ABTB1 is implicated in cellular processes such as cell cycle regulation, protein stability, and viral replication .

Research Applications

ABTB1 antibodies are critical in studying:

• Cell Cycle Regulation: ABTB1 inhibits G1/S transition .

• Viral Pathogenesis: Facilitates influenza A virus replication by degrading TRIM4, which stabilizes viral NP protein .

• Protein Stability: Interacts with ubiquitin ligases (e.g., CUL3) to regulate proteasomal degradation .

Role in Influenza A Virus (IAV) Replication

ABTB1 antibodies have elucidated a novel mechanism where ABTB1 promotes IAV replication by:

1. Counteracting TRIM4: ABTB1 degrades TRIM4 via proteasomal pathways, stabilizing viral NP and enhancing vRNP nuclear import .

2. Enhancing Viral NP Stability: Overexpression of ABTB1 accelerates NP nuclear localization and synthesis .

Data from source .