ACBD3 Antibody
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Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. Delivery times may vary depending on the purchasing method and location. Please consult your local distributors for specific delivery times.
Synonyms
ACBD 3 antibody; ACBD3 antibody; Acyl CoA binding domain containing protein 3 antibody; Acyl Coenzyme A binding domain containing 3 antibody; Acyl-CoA-binding domain-containing protein 3 antibody; GCP 60 antibody; GCP60 antibody; GCP60_HUMAN antibody; GOCAP 1 antibody; GOCAP1 antibody; Golgi complex associated protein 1 60kDa antibody; Golgi complex associated protein 1 antibody; Golgi complex-associated protein 1 antibody; Golgi phosphoprotein 1 antibody; Golgi resident protein GCP60 antibody; GOLPH 1 antibody; GOLPH1 antibody; PAP 7 antibody; PAP7 antibody; PBR and PKA associated protein 7 antibody; PBR associated protein antibody; PBR- and PKA-associated protein 7 antibody; Peripheral benzodiazepine receptor associated protein PAP7 antibody; Peripheral benzodiazepine receptor-associated protein PAP7 antibody; Peripherial benzodiazepine receptor associated protein antibody; PKA (RIalpha) associated protein antibody
Target Names
ACBD3
Uniprot No.
Target Background
Function
ACBD3 plays a crucial role in maintaining Golgi structure by interacting with giantin. This interaction influences protein transport between the endoplasmic reticulum and the Golgi apparatus. Furthermore, ACBD3 is involved in hormone-induced steroid biosynthesis within testicular Leydig cells. It acts as a recruiter of PI4KB to the Golgi apparatus membrane, enhancing the enzyme activity of PI4KB through membrane recruitment. This process increases the local concentration of the substrate near the kinase. In the context of microbial infections, ACBD3 plays a critical role in Aichi virus RNA replication by recruiting PI4KB to viral replication sites.
Gene References Into Functions
- These findings reveal a mechanism of EV71 replication that involves host ACBD3 for viral replication. PMID: 28303920
- The research suggests that ACBD3 may be a potential therapeutic target for eliminating breast cancer stem cells. PMID: 29307786
- ACBD3 has been identified as a gene expression variability marker in 8-cell human embryos. PMID: 26288249
- The study demonstrates that the machinery components, OSBP, VAP, SAC1, and PITPNB, are essential host factors for AiV replication. Importantly, this machinery is directly recruited to the RNA replication sites through previously unknown interactions between VAP/OSBP/SAC1 and the AiV proteins, along with ACBD3. PMID: 29367253
- Research indicates that Aichi virus 3A protein activates the lipid kinase activity of PI4KIIIb, with ACBD3 enhancing this activation. The interfaces between PI4KIIIbeta-ACBD3 and ACBD3-3A have been mapped using hydrogen-deuterium exchange mass spectrometry. PMID: 27989622
- Kobuviral non-structural 3A proteins function as molecular harnesses to hijack the host ACBD3 protein. PMID: 28065508
- The proposed model suggests that the interaction between Salmonella enterica serovar Typhimurium SseF and SseG enables both proteins to bind ACBD3, anchoring Salmonella-containing vacuoles at the Golgi network and facilitating bacterial replication. PMID: 27406559
- These findings suggest that ACBD3 significantly impacts cellular NAD(+) metabolism by regulating PARP1 activation-dependent auto-modification, thus affecting cell metabolism and function. PMID: 25940138
- Researchers discovered that NS5A and PI4KB compete for association with acyl-coenzyme A binding domain containing protein 3 (ACBD3), which inhibits hepatitis C virus replication. PMID: 24792752
- The complex formed by host ACBD3, PI4KIIIBETA, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is crucial for viral replication. PMID: 24672044
- ACBD3 mediates mHtt cytotoxicity through a Rhes/mHtt/ACBD3 complex. PMID: 24012756
- The Golgi protein acyl-coenzyme A binding domain-containing 3 (ACBD3) interacts with the 3A proteins of poliovaccine Sabintpe 2 and coxsackievirus A17 at viral RNA replication sites. PMID: 23926333
- ACBD3 plays a critical role in maintaining lipid homeostasis by regulating SREBP1's processing pathway, thus impacting cellular lipogenesis. PMID: 23166793
- ACBD3 has been identified as an interacting partner of PPM1L, and this association, which recruits PPM1L to ER-Golgi membrane contact sites, is mediated by a GOLD (Golgi dynamics) domain in ACBD3. PMID: 22796112
- The data supports the interaction of PAP7 with DMT1 and its regulation of DMT1 expression in K562 cells by modulating the expression of DMT1 protein. PMID: 22383495
- The 3A protein of picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta. PMID: 22258260
- Research indicates that a viral protein/ACBD3/PI4KB complex is formed to synthesize PI4P at the AiV RNA replication sites and plays an essential role in viral RNA replication. PMID: 22124328
- Molecular cloning, chromosomal localization, and expression pattern of PAP7 have been studied. PMID: 12692076
- GCP60 exhibits a preference for interacting with one of the golgin-160 caspase cleavage fragments (residues 140-311). This strong interaction prevented the golgin-160 fragment from accumulating in the nucleus when both fragments were overexpressed. PMID: 16870622
- Nuclear translocation of golgin-160-(140-311) is a highly coordinated event regulated not only by cleavage of the golgin-160 head but also by the oxidation state of GCP60. PMID: 17711851
Database Links
Subcellular Location
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion.
Tissue Specificity
Ubiquitous, with highest expression in testis and ovary.
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