2A6 Antibody
Description
CD26-Targeting 2A6 Antibody
Target Protein: CD26 (Dipeptidyl Peptidase IV, DPP IV)
Host Species: Mouse
Applications: Flow cytometry, T cell activation studies
Key Features:
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Recognizes a 110 kDa transmembrane glycoprotein expressed on T cells, B cells, and natural killer (NK) cells .
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Plays roles in extracellular matrix interactions, T cell activation, and immune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) .
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Exhibits dipeptidyl peptidase IV (DPP IV) enzymatic activity, influencing tumor progression and viral infections .
Research Findings:
RRAS-Targeting 2A6 Antibody
Target Protein: RRAS (Related RAS Viral Oncogene Homolog)
Host Species: Mouse
Applications: Western blot (WB), ELISA, immunoprecipitation (IP)
Key Features:
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Detects human RRAS, a GTPase involved in cell adhesion and signaling .
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Unconjugated format allows flexibility in secondary antibody pairing .
Functional Insights:
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Regulates folate cycle enzymes, supporting DNA synthesis and repair .
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Used to distinguish astrocytes from other glial cells in neurological research .
EBV gH/gL-Targeting 2A6 Antibody
Target Protein: Epstein-Barr Virus (EBV) Glycoprotein H/L Complex
Host Species: Human
Applications: Viral neutralization assays, B cell/epithelial cell infection studies
Key Findings:
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Binds the EBV gH/gL complex but exhibits weaker neutralization (IC₅₀: 0.057 µg/mL) compared to antibody 1D8 .
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Structural analysis reveals binding to the D-I/D-II domain interface of gH/gL, partially inhibiting membrane fusion .
Comparative Efficacy:
| Antibody | Neutralization IC₅₀ (µg/mL) | Target Cell Types |
|---|---|---|
| 2A6 | 0.057 | B cells, epithelial cells |
| 1D8 | 0.008 | B cells, epithelial cells |
Product Specs
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
