ACD11 Antibody
Description
ACD11 Antibody Overview
ACD11 antibodies target the ACAD11 protein, a 780-amino-acid enzyme critical for catalyzing the oxidation of acyl-CoA derivatives in mitochondria . Key characteristics include:
| Property | Details |
|---|---|
| Target Function | Fatty acid β-oxidation and amino acid metabolism |
| Associated Diseases | Marfan Syndrome, von Hippel-Lindau syndrome, metabolic disorders |
| Species Reactivity | Human, mouse, rat |
ACAD-11 Antibody (B-12)
-
Applications: Western blot (WB), immunoprecipitation (IP), immunofluorescence (IF), ELISA
-
Conjugates: HRP, FITC, PE, Alexa Fluor® variants (e.g., AF488, AF647)
-
Catalog Variants:
Product Name Catalog # Price ACAD-11 Antibody (B-12) sc-514027 $316.00 ACAD-11 Antibody (B-12) FITC sc-514027 FITC $330.00
ACAD11 Antibody (ABIN6259712)
Research Applications
ACD11 antibodies have been utilized to:
-
Investigate ACAD11’s role in energy metabolism in cardiac and skeletal muscle .
-
Study mutations linked to metabolic disorders (e.g., destabilizing A15T and A39D mutations in the GLTP domain) .
-
Analyze protein expression patterns under stress conditions, such as pathogen infection or nutrient deprivation .
ACAD11 in Disease and Pathology
-
Metabolic Disorders: ACAD11 mutations disrupt lipid metabolism, leading to ceramide accumulation and apoptosis .
-
Cancer: Overexpression correlates with tumor progression due to altered fatty acid oxidation .
-
Autoimmunity: In plants (Arabidopsis), ACD11 homologs regulate programmed cell death (PCD) during pathogen defense, though this mechanism is distinct from human ACAD11 .
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- In the acd11-1 null mutant, the normally low ceramide-1-phosphate increases, but phytoceramide rises acutely. PMID: 24412362
- Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor. PMID: 20949080
- Lazarus1 (AT4G38360) contributes to programmed cell death associated with acd11 and the hypersensitive response. PMID: 20830211
- Site-specific mutants were generated in ACD11 based on homologous GLTP residues required for glycolipid transfer. These ACD11 mutant forms were found to be impaired in their in vitro transfer activity of sphingolipids. PMID: 18657186
- ACD11 function may be related to the regulation of membrane compartments. PMID: 18845362
