acr-16 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
acr-16 antibody; Ce21 antibody; F25G6.3Acetylcholine receptor subunit alpha-type acr-16 antibody
Target Names
acr-16
Uniprot No.
Target Background
Function
Upon acetylcholine binding, the AChR undergoes a significant conformational change impacting all subunits. This change leads to the opening of an ion-conducting channel across the plasma membrane. A subunit of the levamisole-insensitive nicotinic receptor.
Gene References Into Functions
- Xenopus laevis RIC-3 is more effective than its human or C. elegans homologs in chaperoning the expression of nematode nicotinic receptor ACR-16. PMID: 22970690
- Receptors containing ACR-16 are responsible for all non-levamisole-sensitive nicotinic synaptic signaling at the C. elegans neuromuscular junction. PMID: 15917232
Database Links
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=The cam-1 protein is required for correct localization.
Tissue Specificity
Expressed in the body wall muscle.
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