ACSL6 Antibody
Description
Introduction to ACSL6 Antibody
The ACSL6 antibody is a polyclonal or monoclonal immunoglobulin designed to detect acyl-CoA synthetase long-chain family member 6 (ACSL6), an enzyme critical in fatty acid metabolism and lipid biosynthesis. It is widely used in research to study ACSL6's role in diseases such as cancer, metabolic disorders, and neurodegenerative conditions. Below is a detailed analysis of its technical specifications, applications, and research findings.
3.1. Fatty Acid Metabolism Studies
ACSL6 antibodies are used to study lipid synthesis and oxidation pathways. For example:
-
Jurkat and Raji cells (human T-cell and B-cell lines) are recommended positive controls for detecting ACSL6 in fatty acid metabolic studies .
-
In rat myotubes, ACSL6 knockdown reduces lipid droplet accumulation and enhances mitochondrial oxidative capacity via AMPK/PGC1-α signaling, as shown in WB experiments .
3.2. Neuroprotection and Cancer Research
-
Brain-specific expression: Proteintech's antibody detects ACSL6 in mouse and rat brain tissues, correlating with its role in neuroinflammation and DHA (docosahexaenoic acid) biosynthesis .
-
Cancer biomarker: ACSL6 overexpression is linked to hepatocellular carcinoma and neuroblastoma, making it a potential therapeutic target .
4.1. Lipid Metabolism
4.2. Neuroprotection
-
DHA deficiency: Acsl6 knockout mice show reduced brain DHA levels, linked to elevated neuroinflammation and astrogliosis (e.g., GFAP upregulation) .
-
Astrocyte-specific knockout (Acsl6 G−/−) exacerbates LPS-induced inflammation, suggesting a protective role in neuroinflammatory responses .
References
-
Thermo Fisher Scientific. (2025). "ACSL6 Polyclonal Antibody (PA5-30465)."
-
PMC. (2016). "Long‐chain acyl‐CoA synthetase 6 regulates lipid synthesis and mitochondrial biogenesis in skeletal muscle."
-
Thermo Fisher Scientific. (2024). "ACSL6 Polyclonal Antibody (PA5-99052)."
-
PNAS. (2018). "Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acids in brain."
-
Proteintech. (2025). "ACSL6 Antibody (13847-1-AP)."
Product Specs
Target Background
- ACSL6 directs acyl-CoA towards lipid synthesis. Downregulation of ACSL6 improves mitochondrial biogenesis, respiratory capacity, and lipid oxidation. PMID: 27647415
- Variations in the ACSL6 gene may be associated with the number of cigarettes smoked. PMID: 22205969
- The alternative fatty acid Gate-domain motifs are critical determinants for the activity of human ACSL6 isoforms, which appear to function as homodimeric enzymes as well as in complexes with other spliced forms. PMID: 20429931
- The t(5;12)(q23-31;p13) translocation with ETV6-ACSL6 genomic alteration rearrangement has been reported in polycythemia vera patients. PMID: 16572202
- Studies have not yielded convincing evidence for associations between schizophrenia and ACSL6. PMID: 16827919
- Three ACSL6 spliced variants of a mutually exclusive exon pair have been reported, which encode a slightly different short motif containing a conserved structural domain, the fatty acid Gate domain. PMID: 16834775
- Haplotypes within the SPEC2/PDZ-GEF2/ACSL6 region have been associated with schizophrenia. PMID: 17030554
- The acyl-coenzyme A synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 has been associated with premature ovarian failure, and disease-susceptibility haplotypes have been identified. PMID: 18555221
- ACSL6 is strongly associated with schizophrenia. Several haplotypes within this haploblock have shown a 2- to 10-fold increase in affected individuals in Han Chinese populations. PMID: 18718982
