ADARB1 Antibody

1. Adenosine-to-inosine editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts, and significantly hypoedited in glioblastoma multiforme. This hypoediting correlates with downregulation of ADAR2. PMID: 28550310
2. The deaminase domain-RNA contact surfaces are reviewed, and models of how full-length ADARs, bearing double-stranded RNA-binding domains (dsRBDs) and deaminase domains, could process naturally occurring substrate RNAs are presented. PMID: 28217931
3. A two-way interaction between TPH2 rs4290270 and general traumas revealed that individuals with TT homozygotes and a history of general traumas had an increased risk for suicide attempts. A three-way interaction of general traumas, TPH2 rs4290270, and ADARB1 rs4819035 indicated that the highest predisposition to suicide attempts was observed in individuals who experienced general traumas and were TT homozygotes for both rs4290270 and rs4819035. PMID: 28084537
4. Four crystal structures of the human ADAR2 deaminase domain bound to RNA duplexes bearing a mimic of the deamination reaction intermediate have been determined. PMID: 27065196
5. The importance of specific amino acids at 19 different positions in the ADAR2 5' binding loop was determined, revealing six residues that provide essential structural elements supporting the fold of the loop and key RNA-binding functional groups. This research provided new insights into RNA recognition by ADAR2 and established a new tool for defining structure-function relationships in ADAR reactions. PMID: 27614075
6. Data indicate that ADAR2 suppresses tumor growth and induces apoptosis by editing and stabilizing IGFBP7 in esophageal squamous cell carcinoma. PMID: 28035363
7. These findings suggest that adenosine deaminase acting on RNA 2 is subject to different regulations by DNA methyltransferase and histone deacetylase enzymes in neuronal SH-SY5Y cells. PMID: 26485095
8. These data suggest that, similar to ADAR2, underlying sequences in dsRNA may influence how NF90 recognizes its target RNAs. PMID: 26712564
9. Detailed structural analysis indicates that the minor groove width of dsRNA and the global shape of RNA may play a crucial role in the specific reading mechanism of ADAR2. PMID: 26252972
10. The research concludes that this aberrant alternative splicing pattern of ADAR2 downregulates A-to-I editing in glioma. PMID: 25873329
11. ADARB1 rs9983925 and rs4819035 and HTR2C rs6318 were associated with suicide attempt risk. PMID: 25732952
12. ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. PMID: 25582055
13. The ADAR2 alternative splicing variants may be correlated with the invasiveness of gliomas. PMID: 24509948
14. Characterization of the ADAR2 catalytic domain-RNA interaction. PMID: 25564529
15. ADAR2-mediated editing of the complementary antisense transcripts is a novel mechanism for regulating the biogenesis of specific miRNAs during hepatocarcinogenesis. PMID: 24386085
16. Altered RNA editing efficiency of AMPA receptors due to down-regulation of ADAR2 may play a role in the pathophysiology of mental disorders. PMID: 24443933
17. The results represent the first evidence that the ADAR1 p150 isoform is the determinant of DSH and may provide insights into the currently unknown mechanisms involved in the development of DSH. PMID: 23621630
18. Findings demonstrate that post-transcriptional A-to-I RNA editing might be crucial for glioblastoma pathogenesis, identify ADAR2-editing enzyme as a candidate tumor suppressor gene, and provide proof that ADAR2 may represent a suitable target. PMID: 22525274
19. ADAR2 activity does not consistently change due to the overexpression or knockdown of TDP-43 or the expression of abnormal TDP-43 in amyotrophic lateral sclerosis (ALS) motor neurons. PMID: 22414730
20. ADAR2 activity at the GluA2 pre-mRNA Q/R site correlates with the ADAR2 mRNA level relative to the GluA2 pre-mRNA in different cultured cell lines. PMID: 22366356
21. These results indicated that ADAR2 downregulation is a profound pathological change relevant to the death of motor neurons in ALS. PMID: 22226999
22. The strong functional similarity of human ADAR2 and Drosophila Adar suggests that these are true orthologs. PMID: 21622951
23. The authors found that, analogously to ADAR1, ADAR2 enhances the release of progeny virions by an editing-dependent mechanism. PMID: 21289159
24. Elucidation of the molecular mechanism underlying the co-occurrence of reduced ADAR2 activity and abnormal TDP-43 pathology in the same motor neurons may provide a clue to the neurodegenerative process of sporadic amyotrophic lateral sclerosis. PMID: 20372915
25. The high conservation of the novel ADAR2 alternative exon in mammals indicates a physiological importance for this exon. PMID: 20215858
26. Overexpression inhibits HDV RNA replication and compromises virus viability. PMID: 11907222
27. Adenosine to inosine RNA editing requires formation of a ternary complex on the GluR-B R/G site. PMID: 12163487
28. Short inhibitory RNA-mediated knockdown of host ADAR1 expression, but not that of ADAR2, led to decreased HDV amber/W editing and virus production. PMID: 12414985
29. The Q/R site of GluRs editing is regulated in a regional manner, and the GluR2 Q/R site editing is critically regulated by ADAR2 in the human brain. PMID: 12859334
30. Enzymatic activity of N-terminal deletion constructs of hADAR2 was assayed to determine the role of the double-stranded RNA binding motifs and the intervening linker peptide. PMID: 15383678
31. Inositol hexakisphosphate is buried within the catalytic domain of ADAR2 and is required for editing of transfer RNA. PMID: 16141067
32. Results show that bipolar affective disorder may not be caused by mutations in ADARB1. PMID: 16733555
33. Serum adenosine deaminase (ADA) activity of active Behcet's disease (BD) was higher than that of inactive BD (P < 0.01), but erythrocyte ADA activity was found to be lower in active BD than inactive BD (P < 0.01). PMID: 16961545
34. CD26 and cell surface adenosine deaminase are selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma. PMID: 17071493
35. The CTD of POLR2A and ADAR2 function together to enforce the order of events that allows editing to precede splicing, and they furthermore suggest a new role for the CTD as a coordinator of two interdependent pre-mRNA processing events. PMID: 17525170
36. Reference values of serum adenosine deaminase (ADA) in normal pregnancy may provide important database for making clinical decisions in pregnancies complicated by conditions where cellular immunity has been altered. PMID: 17728516
37. Analysis of a splice variant that extends the open reading frame of ADAR2 by 49 amino acids through the utilization of an exon located 18 kilobases upstream of the previously annotated first coding exon and driven by a candidate alternative promoter. PMID: 19156214
38. Our understanding of the importance of functional groups found in the edited nucleotide and the role of specific active site residues of ADAR2. PMID: 19642681

Show More

Hide All

HGNC: 226

OMIM: 601218

KEGG: hsa:104

STRING: 9606.ENSP00000353920

UniGene: Hs.474018