ADIPOR2 Antibody

1. A study conducted in an admixed Latin American population did not reveal any significant associations between ADIPOR2 and diabetes or hypertriglyceridemia. PMID: 29145541
2. The findings of a case-control study highlight the role of AdipoR2 genetic polymorphisms (rs10773989 and rs1044471) and its protein expression in the development and progression of colorectal cancer. PMID: 28765899
3. Two polymorphisms, rs2241766 in the ADIPOQ gene and rs10773989 in the ADIPOR2 gene, particularly under a recessive inheritance model, were found to be independent risk factors for myocardial infarction in Han Chinese populations. PMID: 29524572
4. Research indicates that globular adiponectin inhibits the pro-oncogenic effects of leptin by suppressing UHRF1 via the AdipoR2 pathway. PMID: 28285359
5. Variations in the ADIPOR2 gene could be a determinant for higher free fatty acid (FFA) levels. In Chinese Han populations, carriers of the CT and TT genotypes for rs2370055, even with normal glucose levels, exhibit significantly higher susceptibility to insulin resistance. PMID: 27348122
6. Studies demonstrate that the PAQR-2 and AdipoR2 proteins share a conserved function that maintains membrane fluidity in the presence of exogenous saturated fatty acids. PMID: 28886012
7. Adiponectin's protective effect on the kidneys is associated with improved endothelial function, reduced oxidative stress, and increased endothelial nitric oxide synthase expression. This effect is mediated through the activation of adenosine 5'-monophosphate-activated protein kinase (AMPK) by AdipoR1 and the activation of peroxisome proliferator-activated receptor (PPAR)-alpha signaling pathway by AdipoR2. PMID: 28402446
8. The crystal structure of ADIPOR2 bound to a free fatty acid (FFA) molecule reveals that ADIPOR2 possesses inherent basal ceramidase activity, which is enhanced by adiponectin. PMID: 28329765
9. Adiponectin stimulates the expression of cPLA2 and COX-2 through the AdipoR1/2-dependent activation of PKC/NADPH oxidase/mitochondria, leading to increased reactive oxygen species (ROS) accumulation, p300 phosphorylation, and histone H4 acetylation. PMID: 27288489
10. Research suggests that miR-150 can mitigate oxidized low-density lipoprotein (LDL)-induced lipid accumulation in macrophages by promoting cholesterol efflux. This effect is achieved by targeting AdipoR2, leading to a reduction in macrophage foam cell formation. PMID: 27216461
11. Decreased expression of ADIPOR2 is linked to polycystic ovary syndrome. PMID: 27075719
12. A strong functional association exists between adipor2, cdh13, and adipoq. PMID: 25388841
13. PCR analysis reveals the expression of adiponectin, AdipoR1, AdipoR2, follicle-stimulating hormone receptor (FSHR), and luteinizing hormone receptor (LHR) in granulosa cells (GCs). After controlling for body mass index (BMI) values, quantitative real-time PCR (qRT-PCR) demonstrates a reduced expression of the adiponectin system in GCs of patients with polycystic ovary syndrome compared to controls. PMID: 26631404
14. Increased expression of AdipoR2 (and AdipoR1) gene receptors is linked to the proliferation of endometrial stromal cells. PMID: 26459399
15. Studies identify miR-375 and its direct target, ADIPOR2, as androgen-regulated molecules, suggesting a significant role in the mechanism underlying increased visceral fat mass and associated insulin resistance caused by testosterone deficiency. PMID: 26219823
16. Two ADIPOR2 single-nucleotide polymorphisms (SNPs), rs11061925 and rs929434, were associated with fasting plasma triglyceride concentrations in a cohort of HIV-infected patients. PMID: 26111083
17. Research demonstrates that upregulation of neutrophil AdipoRs (AdipoR1, AdipoR2) is associated with early stages of vascular injury, hypertension severity, and low serum adiponectin levels. PMID: 26146630
18. Studies indicate that the non-conserved N-terminal domains dictate the cell-surface expression and temporal signaling profiles of AdipoR1 and AdipoR2. PMID: 25892445
19. Data suggest the thermal stability of purified N-terminally truncated mutants of adiponectin receptors AdipoR1 and AdipoR2. PMID: 25575462
20. This study indicates that adiponectin may contribute to the progression of colorectal adenomatous polyps to carcinoma through actions on adipo-R1 and adipo-R2 receptors. PMID: 25640382
21. Crystal structures of the human adiponectin receptors AdipoR1 and AdipoR2 at 2.9 Å and 2.4 Å resolution, respectively, have been determined. PMID: 25855295
22. Down-regulation of adiponectin receptors (AdipoR1, R2, and T-cadherin) in osteoarthritic chondrocytes has been observed. PMID: 24888493
23. These findings further support the role of AdipoR2 in the progression of prostate cancer. PMID: 25863129
24. The AA genotype and A allele of rs12342 in the adiponectin receptor 2 gene may increase the risk of ischemic stroke, particularly the risk of atherosclerosis cerebral infarction. PMID: 25299095
25. miR-423-3p plays a novel oncogenic role in laryngeal cancer through the suppression of AdipoR2. PMID: 25337209
26. Collectively, these studies suggest that adiponectin influences bone metabolism by reducing bone formation levels. PMID: 24673523
27. The improvement in insulin sensitivity induced by physical exercise is linked to alterations in adiponectin and/or AdipoR1/R2 expression levels. PMID: 25126860
28. Macrophage polarization plays a key role in regulating AdipoR expression and the differential inflammatory responses elicited by APN in macrophages. PMID: 25392268
29. In patients with advanced stage gastric cancer, low Adipo-R1 expression was observed in 17.9% (7 out of 39) and low Adipo-R2 expression in 41% (16 out of 39). PMID: 24969908
30. Low ADIPOR2 expression is associated with hepatocellular carcinoma. PMID: 24619866
31. AdipoR1 stimulates IL10 production by activating the AMPK and MAPKp38 pathways, while AdipoR2 modifies inflammatory processes by activating the COX-2 and PPARG pathways. PMID: 25261236
32. Adiponectin receptors (AdipoR1 and -R2) are located, or re-located, in the plasma membrane, with a distribution in the cytoplasm when mononuclear cells are committed to differentiating into osteoclasts. PMID: 23971629
33. AdipoR2 is regulated by the LH receptor function via a cAMP-dependent mechanism. PMID: 23779096
34. Single-nucleotide polymorphisms (SNPs) in both the adiponectin gene and its receptors AdipoR1 and AdipoR2 (including their haplotypes) are considered candidate genes involved in the development of insulin resistance. PMID: 23656997
35. Studies suggest that altered levels of adiponectin and leptin or their cognate receptors in cancers can ultimately lead to an imbalance in downstream molecular pathways. PMID: 23355630
36. APN, AdipoR1, and AdipoR2 are present in human and mouse retinas. Retinal APN and AdipoR1 protein levels are elevated in type 1 diabetes mellitus mice. PMID: 23922494
37. Collectively, these studies demonstrate that the non-conserved region of AdipoR2 restricts its cell-surface expression, raising the possibility that the majority of cell-surface AdipoR2 may exist as heterodimers. PMID: 23376713
38. Data indicate that AdipoR1 was expressed in 27% of primary tumors and AdipoR2 in 47%. PMID: 22907586
39. High AdipoR2 expression is associated with gastric carcinoma. PMID: 23358721
40. Circulating adiponectin concentrations were not affected by type 1 diabetes. However, expression of adiponectin receptors on blood monocytes was significantly reduced and inversely associated with insulin resistance. PMID: 23386639
41. The pleiotropic, tissue-dependent functions of adiponectin are dependent on the expression levels of AdipoR1 and AdipoR2. PMID: 23255609
42. Reduced hepatic expression of adiponectin and adipoR2 may be relevant to the pathophysiology of chronic hepatitis B patients with metabolic syndrome. PMID: 22819899
43. Increased mRNA and protein expression of adiponectin receptors is associated with increased aortic stiffness and coronary and peripheral atherosclerosis in patients with coronary artery disease. PMID: 22534793
44. Adiponectin differentially regulates the expression of Adipor1/Adipor2, as well as genes related to steroidogenesis, ovulation, and apoptosis in cumulus cells compared to granulosa cells. PMID: 22633650
45. Adiponectin receptor-2 795G/A polymorphisms and their relation to insulin resistance have been investigated. PMID: 22187345
46. In a Finnish type 2 diabetes population, four SNPs in ADIPOR2 (rs10848554, rs11061937, rs1058322, rs16928751) were associated with cardiovascular disease risk, and two of these remained significant. PMID: 21943112
47. While a decrease in leptin receptor levels in chronic myeloid leukemia patients was confirmed, the increase in AdipoR1 levels and corresponding decrease in AdipoR2 levels suggest their potential involvement in the pathogenesis of chronic myeloid leukemia. PMID: 22082804
48. Researchers evaluated 29 common single-nucleotide polymorphisms (SNPs) in ADIPOQ (n = 13), ADIPOR1 (n = 5), and ADIPOR2 (n = 11) in relation to the risk of prostate cancer. PMID: 21960694
49. Adiponectin's suppression of macrophage lipid accumulation/foam cell formation is mediated through the AdipoR1/AdipoR2/APPL1 pathway. AdipoR1 and AdipoR2 exhibit different abilities to regulate inflammatory cytokines and SR-A1. PMID: 22227293
50. In vitro and ex vivo evidence supports a causal role for adiponectin in endometrial cancer. PMID: 21980131

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HGNC: 24041

OMIM: 607946

KEGG: hsa:79602

STRING: 9606.ENSP00000349616

UniGene: Hs.371642