Aebp1 Antibody
Description
Introduction to AEBP1 Antibody
AEBP1 (Adipocyte Enhancer-Binding Protein 1) antibodies are specialized tools used to detect and study the AEBP1 protein, a transcriptional repressor with roles in adipogenesis, inflammation, and cancer progression. These antibodies enable researchers to investigate AEBP1's expression patterns, isoforms (full-length ACLP and truncated AEBP1), and functional mechanisms in both physiological and pathological contexts .
Applications in Research
AEBP1 antibodies are critical for studying the protein’s roles in:
Neurodegenerative Diseases
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Alzheimer’s Disease (AD): AEBP1 is upregulated in hippocampal pyramidal neurons and astrocytes in AD brains. Immunohistochemistry reveals its association with pretangle neurons and dystrophic neurites in senile plaques .
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Mechanism: AEBP1 activates NF-κB, promoting neuroinflammation and tau pathology .
Cancer Biology
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Gastric Cancer (GC):
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Colorectal Cancer (CRC): AEBP1 promotes angiogenesis and tumor growth via NF-κB/MMP-2 signaling .
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Glioma: AEBP1 overexpression in glioblastoma stem cells (GSCs) drives temozolomide resistance and poor prognosis .
Immunocyte Infiltration
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AEBP1 expression correlates with immune cell infiltration (macrophages, neutrophils, CD4+/CD8+ T cells) in gastric cancer, suggesting a role in tumor microenvironment modulation .
Research Findings Table
Mechanisms of Action
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NF-κB Pathway: AEBP1 enhances NF-κB activity by promoting IκBα degradation, driving inflammation and cancer progression .
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EMT Regulation: AEBP1 induces epithelial-mesenchymal transition (EMT) via TWIST and MMP-2 upregulation, facilitating metastasis .
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Collagen Remodeling: Isoform 1 (ACLP) regulates extracellular matrix organization, impacting wound healing and fibrosis .
Clinical Implications
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- ACLP stimulates the fibroblast-to-myofibroblast transition by promoting SMA expression through TGFbeta signaling and enhancing collagen expression via a TGFbeta receptor-independent pathway. PMID: 24344132
- Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia through proinflammatory and hedgehog signaling pathways. PMID: 22995915
- Research suggests that macrophage AEBP1 plays significant regulatory roles in atherogenesis, making it a potential therapeutic target for preventing or treating atherosclerosis. PMID: 21687917
- Studies have characterized the pathophysiological features of gastroschisis in aortic carboxypeptidase-like protein knockout mice and investigated the neuromuscular development of the eviscerated intestine. PMID: 20386491
- MAPK regulates the transcriptional activity of AEBP1 through a novel dual mechanism, where MAPK interaction enhances and subsequent phosphorylation decreases the DNA-binding ability of AEBP1. PMID: 15654748
- The developmental expression pattern of AEBP1 is consistent with a regulatory or structural role in the abdominal wall, vasculature, and dermis. PMID: 15749083
- AEBP1 plays critical regulatory roles in macrophage cholesterol homeostasis, foam cell formation, and proinflammation. PMID: 16461908
- NF-kappaB activity is modulated through protein-protein interactions involving AEBP1 and IkappaBalpha. PMID: 17202411
- AEBP1 negatively regulates adipose tissue PTEN levels and plays a key functional role in modulating in vivo adiposity. PMID: 17299101
- Adipocyte enhancer-binding protein 1 (AEBP1) is upregulated during monocyte differentiation. PMID: 19166963
- ACLP and its discoidin-like domain may serve as novel targets for anti-myofibroblast-based therapies for the treatment of pulmonary fibrosis. PMID: 19179605
