AEE22 Antibody

AEBP2 (AE Binding Protein 2) Antibodies

AEBP2 is a zinc finger protein involved in chromatin remodeling and transcriptional regulation. It is a subunit of the Polycomb Repressive Complex 2 (PRC2), which mediates histone H3 lysine 27 trimethylation (H3K27me3), a key epigenetic modification .

Key Research Findings

• Structural Features:

  • AEBP2 contains three zinc finger domains and a C-terminal acidic region critical for PRC2 interaction .

  • Isoforms vary in molecular weight, with full-length human AEBP2 migrating at ~70 kDa and truncated forms at ~28 kDa .

• Functional Roles:

  • Modulates PRC2 activity to maintain gene silencing during development .

  • Linked to adipocyte differentiation and immune regulation in murine models .

Antibody Applications

ACE2 (Angiotensin-Converting Enzyme 2) Antibodies

ACE2 is a transmembrane receptor for SARS-CoV-2 and a regulator of the renin-angiotensin system. Autoantibodies against ACE2 have been identified in COVID-19 patients .

Key Research Findings

• SARS-CoV-2 Interaction:

  • ACE2 antibodies block viral entry by competing with the spike protein’s receptor-binding domain (RBD) .

  • Autoantibodies against ACE2 correlate with disease severity in COVID-19, potentially disrupting ACE2’s enzymatic function .

• Therapeutic Development:

  • Monoclonal antibody ch2H2 targets ACE2’s N-terminal domain, showing broad efficacy against SARS-CoV-2 variants .

  • Adeno-associated virus (AAV)-delivered ACE2 antibodies reduce viral load in murine models .

Clinical Data

EA2 (Calcium Channel Antibodies)

EA2 refers to antibodies targeting the CACNA1A-encoded α1A subunit of voltage-gated calcium channels, associated with neurological disorders .

Key Features

• Clinical Relevance:

  • Linked to episodic ataxia type 2 and spinocerebellar ataxia .

• Commercial Antibodies:

  • Available for ELISA, Western blot, and immunohistochemistry .

Potential Misinterpretations

• Terminology: "AEE22" may represent a typographical error for "AEBP2," "ACE2," or "EA2," given phonetic and functional overlaps.

• Experimental Context: In murine studies, anti-ACE2 antibodies are sometimes labeled by clone numbers (e.g., ch2H2) , but no "AEE22" designation exists in published datasets.

Research Gaps and Future Directions

• AEBP2: Further studies are needed to elucidate its role in autoimmune diseases and metabolic regulation .

• ACE2 Autoantibodies: Longitudinal analyses required to assess post-COVID sequelae and therapeutic implications .