AGD3 Antibody
Description
Understanding Antibodies
Antibodies, or immunoglobulins, are proteins produced by B cells that are crucial for the immune system's defense against pathogens. They are classified into five main types: IgG, IgM, IgA, IgD, and IgE, each with distinct functions and distributions in the body .
Antibody Structure and Function
Antibodies consist of two heavy chains and two light chains, forming a Y-shaped structure. The heavy chains determine the antibody's class (e.g., IgG, IgM), while the light chains can be either kappa (κ) or lambda (λ) . Antibodies bind to specific antigens, helping to neutralize or remove pathogens from the body.
Research on Broadly Reactive Antibodies
Recent studies have focused on identifying broadly reactive antibodies that can target multiple pathogens, such as HIV-1 and influenza A . These antibodies are valuable for developing vaccines and therapeutics against diverse viral strains.
Data Table: Types of Antibodies
| Antibody Type | Heavy Chain | Function | Distribution |
|---|---|---|---|
| IgG | γ | Primary defense against bacterial and viral infections | Bloodstream, tissues |
| IgM | μ | Initial immune response | Bloodstream |
| IgA | α | Mucosal immunity | Mucous membranes, secretions |
| IgD | δ | Induction of antibody production | B cell surface |
| IgE | ε | Allergic reactions | Mast cells |
References:
- Kyowa Kirin. (n.d.). 5 antibody types. Retrieved from https://www.kyowakirin.com/antibody/basics/isotypes.html
- Nature. (2020). Structural and biochemical characterization of the Agd3 protein. Retrieved from https://www.nature.com/articles/s41467-020-16144-5
- Bio-Rad Antibodies. (n.d.). Immunoglobulin Types, Classes and Subclasses. Retrieved from https://www.bio-rad-antibodies.com/immunoglobulins-classes-subclasses.html
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
VAN3 Function and Regulation: Research indicates VAN3's multifaceted role in plant development. Key findings include:
- VAN3, along with ARF-GEF GNOM, both involved in polar auxin transport-dependent morphogenesis, exhibit localization at both the plasma membrane and intracellular structures. PMID: 21118984
- VAN3 expression is induced by auxin and is auto-regulated, with positive feedback by VAN3 itself. PMID: 15743878
- VAN3 is functionally related to Scarface (SFC), which is essential for the proper intracellular trafficking of PIN1 from the plasma membrane to endosomes. PMID: 16698946
- Subcellular targeting and regulation of VAN3's activity are influenced by phosphatidylinositol 4-phosphate [PtdIns(4)P] and/or inositol 1,4,5-trisphosphate [IP(3)], controlling the continuity of plant vascular tissue. PMID: 19363154
- VAN3 participates in vesicle trafficking, and its function in vascular formation is synergistic with DRP1A. PMID: 15923323
