AGD7 Antibody

Introduction to AGD7 Antibody

The AGD7 antibody targets G Antigen 7 (GAGE7), a human protein implicated in cancer biology and immunoregulation. This antibody, cataloged as ABIN1774803, is a mouse-derived polyclonal reagent designed for detecting GAGE7 in research applications, particularly Western Blotting . GAGE7 belongs to the GAGE family of cancer-testis antigens, which are often overexpressed in malignancies but exhibit restricted expression in normal tissues .

Research Applications

• Western Blotting: Validated for detecting GAGE7 in transfected mammalian lysates .

• Cancer Biomarker Studies: GAGE7 is overexpressed in tumors, making this antibody a tool for investigating cancer progression and immunotherapy targets .

Biological Context of GAGE7

While the AGD7 antibody specifically targets human GAGE7, Arabidopsis AGD7 (Arf GTPase-activating protein 7) is a distinct plant protein involved in Golgi trafficking regulation . Key differences:

Human GAGE7

• The AGD7 antibody detects GAGE7 in transfected lysates but requires further validation in clinical tumor samples .

• GAGE proteins like GAGE7 are immunogenic, suggesting utility in cancer vaccine development .

Arabidopsis AGD7 (Unrelated to the Antibody)

• Arabidopsis AGD7 regulates COPI vesicle formation by modulating Arf1-GTP hydrolysis, critical for Golgi-to-ER trafficking .

• Overexpression disrupts Golgi integrity, mimicking Brefeldin A effects .

Critical Considerations

• Species Specificity: The AGD7 antibody is human-specific; plant AGD7 studies use distinct reagents.

• Clinical Relevance: GAGE7’s role in immune evasion warrants exploration using this antibody in cancer models.