AGT3 Antibody
Description
Anti-Human GLUT3 (extracellular) Antibody (#AGT-043)
Target: Human glucose transporter 3 (GLUT3), a protein critical for cellular glucose uptake.
Key Properties
Research Findings:
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Detects extracellular epitopes, enabling live cell surface labeling .
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Does not recognize rodent GLUT3, limiting its use to human-derived samples .
Anti-GLUT3 (extracellular) Antibody (#AGT-023)
Target: Rat and mouse GLUT3.
Key Properties
Research Findings:
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Used to map GLUT3 distribution in brain regions, highlighting its role in neuronal glucose metabolism .
Anti-GABA Transporter 3 (GAT-3) Antibody (#AGT-003)
Target: Rat GABA transporter 3 (GAT-3), involved in neurotransmitter regulation.
Key Properties
Atg3 Antibody (#3415)
Target: Autophagy-related protein 3 (Atg3), essential for autophagosome formation.
Key Properties
| Property | Details |
|---|---|
| Reactivity | Human, mouse, rat, monkey (predicted via sequence homology) |
| Applications | Western blot (1:1000 dilution) |
| Sensitivity | Detects endogenous Atg3 (~40 kDa) |
IgG3 Features Impacting Function
Example: Engineered IgG3 antibodies against SARS-CoV-2 demonstrated 10–100× greater neutralization potency than IgG1 counterparts, attributed to hinge-mediated avidity effects .
Critical Considerations
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Species Specificity: AGT-043 and AGT-023 are mutually exclusive for human vs. rodent studies .
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Epitope Localization: Extracellular (AGT-043, AGT-023) vs. intracellular (AGT-003) targets dictate experimental design .
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Structural Variants: IgG3’s functional plasticity underscores the importance of hinge and Fc modifications in therapeutic antibody design .
Product Specs
Components: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
