AIG2A Antibody

Role of AIG2A in Plant Defense

AIG2A proteins, along with AIG2B, play crucial roles in regulating plant defense systems. They function as gatekeepers that prevent the activation of salicylic acid (SA) defense systems by tryptophan-derived secondary metabolites (TDSMs) in plants . This regulatory mechanism is essential for balancing SA and TDSM defense systems in response to pathogenic and non-pathogenic microbes.

Key Findings:

• Function: AIG2A and AIG2B limit the activation of SA defense systems by TDSMs.

• Localization: These proteins are co-localized with TDSM biosynthetic enzymes.

• Expression: Their gene expression is co-induced with TDSM genes by non-self signals.

Research on AIG2A and AIG2B

Studies on AIG2A and AIG2B have shown that loss of function mutants exhibit enhanced resistance to certain pathogens, such as Pseudomonas syringae pv. tomato DC3000 . The proteins are essential for preventing the overactivation of defense systems, which could otherwise lead to detrimental effects on plant health.

Future Research Directions

Future studies aim to identify the substrates of AIG2A and AIG2B through metabolite profiling and genetic dissections. Understanding these substrates will provide insights into how SA and TDSM defense systems interact .

References:

- AIG2 proteins fine tune plant chemical defense systems - Plantae.org
- AIG2A and AIG2B limit the activation of salicylic acid-regulated defense systems in plants.