Function
ALDH3H1 plays a crucial role in oxidative stress tolerance by detoxifying reactive aldehydes resulting from lipid peroxidation. It exhibits a preference for medium- to long-chain saturated aldehydes as substrates, with the short-chain aldehyde propanal showing significantly weaker substrate affinity. The enzyme is strictly NAD+-dependent.
Gene References Into Functions
- Studies indicate that amino acid residues at positions homologous to 149, 178, and 200 within the ALDH3H1 protein are critical determinants of cofactor binding affinity. (PMID: 24463048)
- The ALDH3H1 locus encodes at least five alternatively spliced transcript variants. (PMID: 22442412)
Protein Families
Aldehyde dehydrogenase family
Tissue Specificity
Isoform alpha is expressed in expanded leaves and flowers. Detected in seedlings. Isoform beta is mainly expressed in flowers. Detected in leaves and seedlings.