ALDH3I1 Antibody
Description
Antibody Overview: ALDH3A1 and ALDH1A3
ALDH3A1 (Aldehyde Dehydrogenase 3 Family Member A1) and ALDH1A3 (Aldehyde Dehydrogenase 1 Family Member A3) are enzymes involved in detoxification, oxidative stress response, and stem cell regulation. Antibodies targeting these proteins are widely used in cancer research, particularly for identifying cancer stem cells (CSCs) and studying metabolic pathways .
Cancer Stem Cell Identification
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ALDH1A3 regulates breast CSC populations by modulating CD24/CD44 expression and metabolic shifts (e.g., oxidative phosphorylation vs. glycolysis) .
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ALDH3A1 is overexpressed in corneal epithelium and protects against UV-induced damage, with implications in ocular biology .
Prognostic Markers in Oncology
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High ALDH1 activity correlates with poor prognosis in breast cancer .
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ALDH1A3 knockdown reduces tumor-initiating capacity in triple-negative breast cancer (TNBC) models .
Table 2: Antibody Performance in Key Assays
Clinical and Therapeutic Implications
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ALDH1A3 inhibitors combined with glycolysis blockers (e.g., 2DG) reduce tumor growth in preclinical models .
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ALDH3A1’s role in UV protection suggests therapeutic potential in corneal diseases .
Limitations and Gaps
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
ALDH3I1 plays a crucial role in oxidative stress tolerance by effectively detoxifying reactive aldehydes generated during lipid peroxidation. It exhibits a preference for medium- to long-chain saturated aldehydes as substrates, while demonstrating weaker affinity towards the short-chain aldehyde propanal. Notably, ALDH3I1 can utilize both NAD(+) and NADP(+) as cofactors, with the coenzyme preference influenced by the specific substrate involved.
- ALDH3I1 and ALDH7B4 exhibit significant induction under heat stress conditions. Notably, ALDH7B4 displays a higher accumulation in response to combined dehydration-heat, heat-salt, and wounding-heat stressors compared to individual stressors. PMID: 28922758
- The constitutive or stress-inducible expression of ALDH3I1 confers tolerance to both osmotic and oxidative stress. PMID: 17080931
