FBA4 Antibody

Introduction to FABP4 Antibody

The FABP4 antibody, also known as the fatty acid-binding protein 4 antibody, is a specific type of monoclonal antibody designed to target FABP4, a protein involved in lipid metabolism. FABP4 is associated with various conditions, including obesity-related diseases and breast cancer. The development of antibodies against FABP4 aims to modulate its activity and potentially treat diseases linked to its dysregulation.

Structure and Function of Antibodies

Antibodies, including those targeting FABP4, are Y-shaped proteins composed of two heavy chains and two light chains. Each chain contains variable and constant domains, with the variable domains responsible for antigen recognition and the constant domains providing structural support and interacting with immune effector molecules . The FABP4 antibody specifically binds to FABP4, potentially inhibiting its function in lipid metabolism.

Research Findings on FABP4 Antibody

Recent studies have focused on developing humanized monoclonal antibodies against FABP4 for therapeutic applications, particularly in breast cancer treatment. These antibodies are generated by immunizing mice with recombinant human FABP4 protein and then selecting hybridomas that produce high-affinity antibodies . The blocking activity of these antibodies is assessed by their ability to inhibit FABP4-mediated processes, such as tumor cell migration.

Table: Key Features of FABP4 Antibody Development

Potential Therapeutic Applications

The FABP4 antibody holds promise for treating conditions associated with dysregulated lipid metabolism. By targeting FABP4, these antibodies may help mitigate the risk factors linked to obesity and related diseases. For breast cancer, inhibiting FABP4 could disrupt the metabolic pathways that support tumor growth and progression.