ALKBH2 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ALKBH2 antibody; At2g22260 antibody; T26C19.8DNA oxidative demethylase ALKBH2 antibody; EC 1.14.11.33 antibody; Alkylated DNA repair protein alkB homolog 2 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 antibody
Target Names
ALKBH2
Uniprot No.
Target Background
Function
ALKBH2 is a dioxygenase enzyme that plays a critical role in DNA repair. It specifically targets alkylated DNA containing 1-methyladenine and 1-ethenoadenine, removing these modifications through oxidative demethylation. This enzyme demonstrates activity on both double-stranded (dsDNA) and single-stranded (ssDNA) substrates, exhibiting a preference for dsDNA. Notably, ALKBH2 confers resistance to the damaging effects of methylating agents such as methylmethanesulphonate (MMS).
Gene References Into Functions
- Research has demonstrated the significant role of ALKBH2 in protecting Arabidopsis against methylation damage within DNA. PMID: 22532610
Database Links
Protein Families
AlkB family
Subcellular Location
Nucleus.
Tissue Specificity
Expressed ubiquitously, including in seedlings, leaves and flowers.
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