ANGPT1 Antibody

1. ERG, an endothelial transcriptional effector, is activated downstream of Ang1 to promote Notch signaling and vascular stability. Ang1 phosphorylates ERG via PI3K/Akt, promoting the formation of an ERG-beta catenin complex. This complex binds to multiple sites in the Dll4 locus, driving Dll4 expression. PMID: 28695891
2. miR-876-5p suppresses proliferation by inhibiting the expression of Ang-1, which in turn regulates the phosphorylation levels of PI3K, AKT, mTOR, and ERK in psoriasic cells. PMID: 29864894
3. Hyperoxia and increased TGFbeta signaling are major contributors to elevated miR34a levels, which mediate injury through angiopoietin-1 in neonatal lungs. PMID: 29079808
4. Elevated Angpt2 levels and reduced Angpt1 levels are positively associated with abnormal cardiac structure. PMID: 27991547
5. Research has revealed a novel role for the miR-204/ANGPT1/TGFbetaR2 axis in tumor angiogenesis. Therapeutic manipulation of miR-204 levels may represent a promising approach in breast cancer. PMID: 27703260
6. VEGF plays a role in the induction of ANGPT1 in skeletal muscle to stimulate angiogenesis. PMID: 29517203
7. No significant difference in liver expression was observed between chronic hepatitis C patients and controls. PMID: 28027429
8. Serum Ang-2 and Ang-1 levels may aid in diagnosing patients with lymphatic anomalies and are concordant with sirolimus response. PMID: 27990590
9. Studies have examined the role of changes in the ratio of angiopoietin-2 (Ang-2) to angiopoietin-1 (Ang-1) levels in hantavirus infections. An imbalance in Ang-2:Ang-1 persists throughout the acute infection phase. PMID: 28734140
10. Bicarbonate buffered PD fluid promotes vessel maturation by upregulating angiopoietin-1 in vitro and in children on dialysis. PMID: 29253861
11. When Tie2 becomes inactivated, important molecular brakes are released in the endothelium, potentiating inflammation and vascular leakage. Angiopoietin-1 and Angiopoietin-2, the ligands of Tie2, regulate its activation status. PMID: 28582314
12. Certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the Angp-1/Angp-2 ratio. PMID: 28766001
13. Research revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period compared to baseline (BC). ANGPT2 was decreased after conditioning treatment but tended to increase from day +7. On day +7, positive correlations were observed between ANGPT1 level, MMP-9, and the time to engraftment. PMID: 28956132
14. Findings indicate that the Angpt-Tie2 system is essential for SC integrity. Impairment of this system underlies POAG-associated pathogenesis, suggesting that Tie2 agonists could be a therapeutic option for glaucoma. PMID: 28920924
15. Ang-1 specifically increases circulating Gr1(+) inflammatory monocytes and enhances monocyte/macrophage retention in atherosclerotic plaques, contributing to atherosclerosis development. PMID: 28069704
16. NOX2, NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells. PMID: 28351775
17. ANG-1, ANG-2, and TIE-2 levels were significantly elevated in the placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception. PMID: 28238760
18. This study is the first to report Ang1's ability to induce MIP-1beta gene expression, protein synthesis, and release from neutrophils. These effects are mediated by PI3K, p38 MAPK, and MEK activation and downstream NF-kappaB activation. PMID: 27632174
19. This study found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 expression in tumor cells predicted poorer prognosis. Data suggest that dual inhibition of Ang-1 and Ang-2 may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer. PMID: 28720059
20. Data show that fibulin-5 strongly binds to the endothelial cell surface, reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1/TIE-2 receptor axis. PMID: 27304216
21. Ang-1 is not a predictive and clinically relevant biomarker in pulmonary hypertension. PMID: 27802345
22. Findings indicate that angiogenesis is a significant event in the development of common skin warts. The upregulation of both Ang1 and -2 and their binding receptor Tie2 may play a role in the angiogenesis associated with the development of these lesions. PMID: 26695562
23. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct. Additionally, it has been demonstrated that the receptor binding domain of the Tie2 ligand Ang-1, but not the receptor binding domain of Ang-2, can independently associate with a5b1 or aVb3. Cooperative Tie/integrin interactions selectively stimulate ERK/MAPK signaling in the presence of both Ang-1 and fibronectin. PMID: 27695111
24. Results have uncovered ZO-1 as part of a signaling node activated by VEGF, but not Ang-1, that specifically modulates endothelial cell proliferation during angiogenesis. PMID: 26846344
25. Immunohistochemical evidence for apoptosis or autophagy was not found. Quantitative staining showed similar expression levels of the angiogenesis regulators VEGF-A, VEGF-receptor 2, and Angpt1 (p = 0.11), but Angpt2 was significantly lower in CKD children (p = 0.01). PMID: 27846250
26. Ang-1 and -2 levels, as well as the Ang-2/Ang-1 ratio, may serve as promising indicators of disease activity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli. PMID: 26945868
27. l-thyroxine increases Ang1 expression and induces bone formation, differentiation, and mineralization in U2OS and MG63 cell lines. PMID: 27569283
28. Hydroxysafflor yellow A promotes angiogenesis in HUVEC cells via the angiopoietin 1/ Tie-2 signaling pathway. PMID: 27894114
29. Findings suggest that aging shifts the balance of the Ang1/Ang2 network, favoring a quiescent state. Activation of endothelial cells in aging might be necessary to enhance wound healing capacities. PMID: 27137842
30. Plasma Ang-1 levels were diminished in Behcet's disease patients, particularly those with vascular involvement. PMID: 25964071
31. The Ang2/Ang1 ratio may be a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and may play a significant role as a therapeutic target. PMID: 27956798
32. Data suggest that ANGPT1 is active in tight junctions and adherens junctions in the up-regulation of pathophysiological angiogenesis in ovarian follicles in ovarian hyperstimulation syndrome. Follicular fluid from women at risk of ovarian hyperstimulation syndrome in Argentina was used in these studies. PMID: 25485810
33. Results suggest that aHSCs increased the expression of Ang-1, resulting in angiogenesis in HCC tissues, thus promoting the growth and metastasis of HCC. PMID: 27358066
34. Results indicate that MCT contributes to endothelial cell growth and tube formation through up-regulation of angiopoietin-1 expression. This suggests that MCT plays a critical role in pancreatic cancer angiogenesis and tumor growth by activating the angiopoietin-1 pathway. PMID: 27240355
35. Angiopoietin 1 levels were significantly higher in nasopharyngeal cancer patients. PMID: 26758427
36. High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TIE2-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 levels tended to inversely correlate with TEMs invasion. PMID: 27111031
37. GTPCH/Ang-1 interaction in stromal fibroblasts and activation of Tie2 on breast tumor cells may play a significant role in supporting breast cancer growth. PMID: 26814432
38. The homeostasis of vascular endothelial function by Ang-1 and Ang-2 is disrupted in macrophage activation syndrome (MAS). The Ang-2/1 ratio was significantly elevated in the active phase of s-JIA. Serum Ang-1 levels were significantly decreased in MAS, while serum Ang-2 levels and the Ang-2/1 ratio were significantly elevated in MAS. PMID: 26908294
39. ANGPT1 may be associated with taxol resistance of nasopharyngeal carcinoma cells. PMID: 26722421
40. ANGPT1, ANGPT2, and VEGF are associated with the development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. PMID: 26489624
41. AGP1 is downregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease. PMID: 26908325
42. This study found that serum Ang-1 levels were significantly higher at 72 hours post-hemorrhage among aSAH patients. PMID: 26208799
43. For the diagnosis of HELLP syndrome, increased levels of ET-1,M30, and Angs-1 [Angiopoietin-1] and -2 [Angiopoietin-2] appear as promising biomarkers after determination of their standardized threshold levels. PMID: 26138305
44. H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. PMID: 25413303
45. Angiopoietin-1 regulates brain endothelial permeability through PTPN-2-mediated tyrosine dephosphorylation of Occludin. PMID: 26090670
46. Genetic variations of ANGPT1 were associated with increased infarct size and disease susceptibility. PMID: 26542693
47. The distribution of other genotypes (rs2507800, rs1954727, and rs1010824 of ANGPT1) was not significantly different between patients with psoriasis vulgaris and healthy controls. PMID: 25753570
48. Malaria in pregnancy is an effect modifier of the association between Ang-1 and placental barrier thickness. PMID: 26090803
49. Ang-1 disrupts TLR4 signaling, resulting in inhibition of LPS-induced inflammatory responses in endothelial cells. This inhibition occurs through selective targeting of IRAK1 and TRAF6 proteins by miR-146b-5p. PMID: 25824148
50. Gingipains from Porphyromonas gingivalis play roles in the regulation of angiopoietin 1 and angiopoietin 2 in human aortic smooth muscle cells. PMID: 26283334

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HGNC: 484

OMIM: 601667

KEGG: hsa:284

STRING: 9606.ENSP00000428340

UniGene: Hs.369675