ANNAT8 Antibody

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Description

NAT8 Antibody

NAT8 is a putative N-acetyltransferase involved in metabolic processes. The Anti-NAT8 Antibody (A38709) is a commercially available reagent with the following characteristics :

Research Utility

  • Detects NAT8 in mouse kidney and liver tissues (40 µg lysate, 1:237.5 dilution) .

  • Used in IHC for human cervical cancer tissue analysis (1:50 dilution) .

ANXA8 (Annexin A8) Antibody

ANXA8 is a calcium-dependent phospholipid-binding protein implicated in cancer progression and endosomal trafficking. The Human Annexin A8/ANXA8 Antibody (AF8105) is a well-characterized tool :

Research Findings

  • Cancer Prognosis: High ANXA8 expression correlates with poor outcomes in ovarian cancer .

  • Cellular Localization: Expressed in endothelial cells of human placenta and upregulated in mammary hyperplasia and pancreatic adenocarcinoma .

Comparative Analysis

FeatureNAT8 AntibodyANXA8 Antibody
Target FunctionMetabolic acetylationCalcium-dependent membrane trafficking
Disease RelevanceNot explicitly reportedCancer progression, poor prognosis
Commercial SourceAntibodies.com (A38709) R&D Systems (AF8105)
Host SpeciesRabbitSheep

Methodological Notes

  • Western Blot: For NAT8, use 8% SDS-PAGE with mouse kidney/liver lysates . For ANXA8, reducing conditions are recommended .

  • IHC Protocols: NAT8 requires paraffin-embedding and antigen retrieval , while ANXA8 staining uses heat-induced epitope retrieval (Antigen Retrieval Reagent-Basic) .

Limitations and Gaps

  • NAT8: Limited data on mechanistic roles in disease.

  • ANXA8: Conflicting reports on isoforms due to gene duplication on chromosome 10q11 .

Product Specs

Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
14-16 week lead time (made-to-order)
Synonyms
ANNAT8 antibody; ANN8 antibody; At5g12380 antibody; T2L20Annexin D8 antibody; AnnAt8 antibody
Target Names
ANNAT8
Uniprot No.

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