Customize AOP3 Antibody

Description

OPA3 Antibody (Target: Optic Atrophy 3 Protein)

OPA3 is a mitochondrial membrane protein linked to autosomal recessive optic atrophy and 3-methylglutaconic aciduria. The OPA3 antibody (68241-1-Ig) from Proteintech is a mouse monoclonal IgG1 antibody validated for western blot (WB) and ELISA applications .

Research Insights

Mutations in the OPA3 gene cause neurodegenerative disorders characterized by optic nerve degeneration and motor dysfunction .
The antibody detects OPA3 in human cell lines (A549, K-562, HEK-293) and is used to study its role in mitochondrial dynamics .

AQP3 Antibody (Target: Aquaporin-3)

AQP3 is a water/glycerol channel protein implicated in cancer progression and immune regulation. Two anti-AQP3 monoclonal antibodies (mAbs) are highlighted below.

Anti-AQP3 mAb (Research-Grade)

Developed using a synthetic peptide (residues 148–157 of mouse/human AQP3), this mAb binds immune cells and suppresses tumor growth .

Tumor Suppression Mechanism

Observation	Experimental Model	Outcome
M1/M2 Macrophage Ratio	CT26/MC38 colorectal tumors	Increased M1 (pro-inflammatory)/M2 (anti-inflammatory) ratio in TAMs
T Cell Function	BALB/c mice	Restored mitochondrial function and proliferation in tumor-infiltrating T cells
Primary Target	Macrophage-depletion study	Anti-tumor effects abolished upon macrophage depletion

Applications and Validation

Application	Sample Type	Key Finding
Immunohistochemistry	Mouse colon	Co-localizes with E-cadherin in distal colon epithelium
Western Blot	Human kidney cells	Detects ~28 kDa band (consistent with AQP3 glycosylation)

Comparative Analysis of OPA3 and AQP3 Antibodies

Feature	OPA3 Antibody	AQP3 Antibody
Primary Role	Mitochondrial dynamics, neurodegeneration	Water transport, tumor immunomodulation
Therapeutic Potential	Limited (research tool)	High (anti-tumor immunotherapy)
Commercial Availability	Yes (Proteintech)	Yes (Alomone Labs, research-grade)

Research Advancements in AQP3-Targeted Therapy

Recent studies demonstrate that anti-AQP3 mAbs:

Attenuate Immunosuppression: Shift tumor-associated macrophages (TAMs) from M2 to M1 phenotype, enhancing T cell cytotoxicity .
Enhance ADCC/ADCP: Antibody-dependent cellular cytotoxicity/phagocytosis improves in in vitro models .

Key Data from Preclinical Models

Parameter	CT26 Model (BALB/c)	MC38 Model (C57BL/6)
Tumor Growth Inhibition	60–70% reduction	50–55% reduction
Immune Cell Binding	Macrophages, T cells, dendritic cells	Same as CT26

Product Specs

Buffer

Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Lead Time

14-16 week lead time (made-to-order)

Synonyms

AOP32-oxoglutarate-dependent dioxygenase AOP3 antibody; EC 1.14.11.- antibody

Target Names

AOP3

Uniprot No.

Q944X7

Target Background

Function

A 2-oxoglutarate-dependent dioxygenase involved in glucosinolate biosynthesis. This enzyme catalyzes the conversion of methylsulfinylalkyl glucosinolates to hydroxyalkyl glucosinolates.

Protein Families

Iron/ascorbate-dependent oxidoreductase family

Quick Inquiry

Personal Email Detected

Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Name*

Email*

Phone

Country

Source

Quantity&Size*

Product Name

Message

AOP3 Antibody