AP3M Antibody
Description
AP3M2 Antibody in Vesicular Trafficking
Target: Adaptor-Related Protein Complex 3 Subunit Mu-2 (AP3M2), a 47 kDa protein involved in lysosomal trafficking and neuronal vesicle formation .
AP-3 Monoclonal Antibody in Hematology
Target: PSI/Hybrid domain (residues 50-62) of Integrin β3 (GPIIIa/CD61) on human platelets .
Functional Profile:
This antibody detects conformational changes in the αIIbβ3 fibrinogen receptor during platelet activation . Structural studies using AP-3 have revealed how PSI domain mutations impair integrin signaling in bleeding disorders .
Comparative Analysis of AP3M Antibody Types
Recent Advancements (2023-2025)
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Structural Biology: Cryo-EM studies using AP3M2 antibodies helped map the AP-3 complex's role in Alzheimer's-related APP trafficking .
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Diagnostic Use: AP-3 clone antibodies are being evaluated for rapid thrombasthenia diagnostics using nanoparticle-enhanced flow cytometry .
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Therapeutic Potential: AP3M2 is emerging as a biomarker in AP-3-deficient Hermansky-Pudlak syndrome .
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- The zip4 mutant, a loss-of-function variant of a putative ortholog of the yeast AP-3 mu subunit, is implicated in protein trafficking between the trans-Golgi network and vacuoles. PMID: 19884248
