ASB9 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze-thaw cycles.
Lead Time
Typically, we can ship your order within 1-3 business days after receiving it. The exact delivery time may vary depending on the shipping method and destination. Please contact your local distributor for specific delivery times.
Synonyms
ASB9 antibody; Ankyrin repeat and SOCS box protein 9 antibody; ASB-9 antibody
Target Names
ASB9
Uniprot No.
Target Background
Function
ASB9, a substrate-recognition component, plays a crucial role in the SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex. This complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically, ASB9 recognizes at least two forms of creatine kinase, CKB and CKMT1A, thereby regulating their activity and stability.
Gene References Into Functions
- A structural model of ASB9 complexed with its substrate, creatine kinase, elucidates a mechanism for dynamic ubiquitin transfer. PMID: 27396830
- Molecular docking analysis yielded a structural model consistent with all available data, suggesting that the N-terminal residues of ASB9(1-252) may reside within one CK active site. This model was validated by enzymatic activity assays and mutational analysis. PMID: 25654263
- ASB9, inherently unstable, forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain. PMID: 23837592
- His103 and Phe107 in hASB9-2 are critical for binding to CKB. PMID: 22418839
- The findings of this study indicate that ASB9 serves as a valuable prognostic marker for colorectal cancer. PMID: 20878058
- ASB9 interacts with the creatine kinase system and exerts a negative regulatory effect on cell growth. PMID: 20302626
- The splice variant of hASB9, hASB9-2 protein, was cloned, overexpressed, and crystallized. The data revealed that the cubic hASB9-2 crystal belongs to space group P4(3)32 with specific unit-cell parameters. PMID: 18680464
- The purified ASB9-2 protein, a splice variant of ASB9 containing a single ankyrin repeat domain, was crystallized and diffracted to 2.2A resolution. PMID: 19275750
Database Links
Protein Families
Ankyrin SOCS box (ASB) family
Subcellular Location
Mitochondrion.
Tissue Specificity
Predominantly expressed in testis, kidney, and liver.
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