ASK5 Antibody
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In Stock 
Description
Overview
ASK1 (MAP3K5) is a serine/threonine kinase involved in apoptosis and stress responses. The ASK1 monoclonal antibody (Clone K52022_9A7) targets residues within its kinase domain and is used in research applications .
Clinical Relevance
Anti-AK5 antibodies are biomarkers for autoimmune limbic encephalitis (LE), characterized by hippocampal inflammation and cognitive deficits .
Clinical and Immunological Features
Pathogenic Mechanism:
Comparative Analysis of Antibody Targets
| Parameter | ASK1 (MAP3K5) Antibody | Anti-AK5 Antibody |
|---|---|---|
| Target Localization | Intracellular kinase | Intracellular metabolic enzyme |
| Primary Application | Apoptosis research | Autoimmune encephalitis diagnosis |
| Therapeutic Potential | Investigational (cancer, neurodegeneration) | Limited (diagnostic biomarker) |
Research Gaps and Future Directions
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ASK5 antibody; At3g60020 antibody; F24G16.290 antibody; T2O9.2SKP1-like protein 5 antibody; AtSK5 antibody
Target Names
ASK5
Uniprot No.
Target Background
Function
ASK5 Antibody plays a crucial role in the ubiquitination and subsequent proteasomal degradation of target proteins. It forms a SCF E3 ubiquitin ligase complex in conjunction with CUL1, RBX1, and an F-box protein. The specificity of this complex is determined by the specific F-box protein present. Within the SCF complex, ASK5 functions as an adapter, connecting the F-box protein to CUL1.
Database Links
Protein Families
SKP1 family
Subcellular Location
Nucleus.
Tissue Specificity
Restricted to inflorescences, especially in the inflorescence meristem (IM).
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