ASR3 Antibody
Description
Anti-Somatostatin Receptor Type 3 (SSTR3) Antibody (ASR-003)
Developed by Alomone Labs, this antibody targets the third intracellular loop of somatostatin receptor type 3 (SSTR3), a G-protein coupled receptor (GPCR) involved in neurotransmission and tumor regulation .
Research Findings
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Neurological Expression: Localizes to cerebellar Purkinje cells, co-staining with parvalbumin (Figure 1A-C) .
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Cancer Relevance: Overexpressed in pancreatic, breast, lung, and prostate tumors .
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Functional Role: Mediates somatostatin’s inhibition of adenylate cyclase and ion channel activity .
Anti-SR3 Antibody (ab224672)
Produced by Abcam, this antibody targets SR3, a protein implicated in lipid droplet formation .
Research Findings
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Cellular Function: Regulates lipid droplet biogenesis and energy homeostasis .
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Tissue Staining: Validated in human pancreatic tissue (paraffin-embedded samples) .
Comparative Analysis of ASR3 Antibodies
| Feature | ASR-003 (Alomone Labs) | ab224672 (Abcam) |
|---|---|---|
| Target | SSTR3 (GPCR) | SR3 (lipid metabolism protein) |
| Primary Use | Neuroscience/cancer research | Metabolic studies |
| Species Reactivity | Human, mouse, rat | Human, mouse |
| Key Application | Co-localization in Purkinje cells | Lipid droplet visualization |
Regulatory Notes
Both antibodies are designated "For Research Use Only" and are not approved for diagnostic or therapeutic applications . Licensing inquiries for commercial use require direct partnership agreements with the manufacturers .
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- ASR3 functions as a transcriptional repressor regulated by microbe-associated molecular patterns (MAMPs)-activated MPK4. This regulation plays a critical role in fine-tuning plant immune gene expression. [ASR3] PMID: 25770109
