ATOH1 Antibody

• Research suggests that KN promotes goblet cell differentiation by regulating Wnt, Notch, and AhR signals and the expression of Hes1 and Hath1. PMID: 29436668
• Tyrosine 78 of Atoh1 has been found to be phosphorylated by a Jak2-mediated pathway specifically in tumor-initiating cells and human Sonic Hedgehog-type medulloblastoma. PMID: 29168692
• ATOH1 expression was consistently observed in recurrent and metastatic SHH medulloblastoma. Chromatin immunoprecipitation sequencing and gene expression profiling have identified potential ATOH1 targets in tumor cells involved in development and tumorigenesis. PMID: 28490517
• Data indicate that the regulation of Atoh1 by the ubiquitin proteasome pathway is essential for hair cell fate determination and survival. PMID: 27542412
• ATOH1 levels are elevated in advanced Merkel cell carcinoma (MCC), suggesting a role for ATOH1 in MCC progression. PMID: 27624714
• Studies provide evidence that Sox2 expression is required for the late stages of progenitor cell differentiation into hair cells and stimulates Atoh1 expression through a concentration-dependent molecular interaction with the 3' enhancer of Atoh1. PMID: 26988140
• Mutations in ATOH1 were not found in a group of children with sensorineural hearing loss. PMID: 26634621
• Downregulation of Hath1 expression promoted proliferation and reduced apoptosis of KUMA5 squamous cell carcinoma cells. PMID: 26648003
• ATOH1 can induce the differentiation of gastric cancer stem cells. PMID: 25950549
• ATOH1 acts in conjunction with other transcription factors to directly regulate the cochlear hair cell phenotype. PMID: 25015561
• Testosterone-bovine serum albumin and Math1 treatment can promote an increase in hair-cell-like cells in the lesser epithelial ridge through proliferation and transdifferentiation. PMID: 25957791
• Atoh1 epigenetic regulation guides hair cell development in the mammalian cochlea. PMID: 26487780
• Atoh1 protein stabilization induced both a cancer stem cell phenotype and a mucinous phenotype, resulting in the acquisition of chemoresistance in colorectal cancer. PMID: 26017781
• Chicken Atoh1 may exhibit intrinsic functional differences compared to mammalian Atoh1. PMID: 25412697
• This review highlights that Atoh1 gene expression in supporting cells leads to their transformation into immature hair cells. PMID: 25648190
• Data suggest that high Atoh1 expression correlates with a favorable prognosis and may serve as a positive prognostic indicator for GIST. PMID: 25400808
• Expression of Hath1, Muc2, cyclin D1, and p27 was also detected in the xenograft tumors. PMID: 23464457
• Atoh1 transfection drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons. PMID: 24904172
• Cotransfection of Pax2 and Math1 strongly stimulates in situ hair cell regeneration in neomycin-damaged cochlear explants. PMID: 24141260
• The transcription factor Atoh1 is both necessary and sufficient for hair cell development. PMID: 23724999
• The Atoh1 protein regulates malignant potential rather than the differentiation phenotype of mucinous colon cancer (MC), suggesting a mechanism by which MC and signet ring cell carcinoma are more malignant than non-mucinous adenocarcinoma. PMID: 23333391
• Nuclear expression of Atoh1 was inversely correlated with the differentiation and primary tumor stage of lung cancers and also the downregulation of the Wnt pathway. PMID: 23030416
• H. pylori up-regulates Hath1 expression by inducing the release of IL-8 in MKN28 cells. PMID: 22786753
• Transfection of hATOH1 in combination with hTCF3 or hGATA3 induced 2-3 times more Pou4f3/GFP cells, and similarly enhanced Pou4f3/GFP and myosin VIIa double-positive cells, compared to hATOH1 alone. PMID: 22985730
• ATOH1 is involved in the differentiation of neurons, secretory cells in the gut, and mechanoreceptors including auditory hair cells. PMID: 22370966
• In vivo conversion of pillar cells and Deiters' cells into immature auditory hair cells by Atoh1 is age-dependent and resembles normal auditory hair cell development. PMID: 22573682
• Atoh1 activates cell proliferation within the normally postmitotic cochlear epithelium. PMID: 22573692
• Ectopic expression of Math1/Atoh1 significantly reduced cell proliferation and altered cell morphology in Barrett esophagus. PMID: 22147253
• Longitudinal cell formation in the small intestine was regulated by the colocalization of Hath1 and Klf4, which converted Paneth cell differentiation into goblet cell differentiation. PMID: 21125297
• Atonal homolog 1 is required for the growth and differentiation effects of Notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. PMID: 20621629
• Immunohistochemistry was used to investigate the expression of Hath1 in 63 neuroendocrine tumors. PMID: 19924642
• ATOH1 maps to 10q21-22 and is a candidate gene for optic nerve aplasia and related syndromes. PMID: 11889557
• Proneural and proneuroendocrine transcription factor expression has been observed in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. PMID: 12209986
• Hath1 may regulate the expression of MUC2, a mucin secreted by goblet cells. Hath1 may also be a novel factor normally repressed as a consequence of activation of the Wnt signaling pathway. PMID: 16382053
• Hath1 is one of the transcriptional regulators for MUC6 and MUC5AC in gastric cancer cells. PMID: 16647036
• Based on these findings, it is hypothesized that Cdx2 is involved in activating Math1 expression in intestinal epithelial cells. PMID: 16831200
• HATH1 is an essential factor in the up-regulation of MUC2 expression that occurs in mucinous cancers and signet ring carcinomas. PMID: 17000673
• GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to a significant alteration of cell status between proliferation and differentiation in colon cancer. PMID: 17241872
• In the chimeric environment, genotypically wild-type cells possessing Math1 have the capacity to differentiate into hair cells by providing appropriate environmental interactions. PMID: 17397818
• Patients with ATOH1-expressing adenocarcinomas may have a poorer prognosis. PMID: 17549667
• ATOH1 activates hairy and enhancer of split 6 transcription through binding to three clustered E boxes of its promoter. PMID: 17826772
• Hath1 protein degradation may be necessary for maintaining the undifferentiated state of colon cancers, and GSK3 inhibitors have potential for use in cancer therapy. PMID: 18275842
• Data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation. PMID: 19243219
• Adult Atoh1-conditional knock-out mice exhibit behavioral deafness, diminished auditory brainstem responses, and disrupted auditory nuclei morphology. PMID: 19741118

HGNC: 797

OMIM: 601461

KEGG: hsa:474

STRING: 9606.ENSP00000302216

UniGene: Hs.532680