ATP1B1 Antibody

• A novel Single Nucleotide Polymorphism (SNP) in ATP1B1 has been implicated in gene regulatory dysfunction leading to QT prolongation in African and Hispanic Americans. PMID: 27988371
• The ratio between FXYD5 and alpha1-beta1 heterodimer determines whether the Na,K-ATPase acts as a positive or negative regulator of intercellular adhesion. PMID: 27142834
• Research has demonstrated the potent inhibition of Chikungunya virus and related alphaviruses by the cardiac glycoside digoxin, highlighting a role for the sodium-potassium ATPase in Chikungunya virus infection. PMID: 27222471
• Expression of miR-26a and miR-29a was significantly downregulated in leukoplakia and cancer tissues, but upregulated in lichen planus tissues. Target gene expression, including ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a, and PI3KR1, was significantly downregulated in at least two of the three disease types compared to normal tissues. PMID: 27515006
• Overexpression of ATP1B1 is associated with cytogenetically normal acute myeloid leukemia. PMID: 26506237
• The Na,K-ATPase b1-subunit is a target of the Shh signaling pathway, and loss of b1-subunit expression may contribute to tumor development and progression in both carcinoma and medulloblastoma, a tumor of neuronal origin. PMID: 26286140
• Impaired regulation and compromised activity of ion channel proteins contribute to the pathophysiology of vascular dementia. PMID: 25152327
• Activities of AE1 and the sodium pump are coregulated in the kidney. PMID: 25012180
• ATP1B1 is epigenetically silenced by promoter methylation in both renal cell carcinoma (RCC) patients' tissues and cell lines. PMID: 24452105
• A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure. PMID: 24098465
• Changes in mRNA and protein expression of Na(+)/K(+)-ATPase subunits were observed in lacrimal glands (LG) from term pregnant rabbits. These changes suggest a role in the pregnancy-related LG secretion changes and dry eye symptoms observed in these animals. PMID: 23009595
• Data show that protein kinase A (PKA) phosphorylation has a significant impact on Na(+)/K(+)-ATPase (NKA) structure and dynamics. PMID: 22433860
• Polymorphisms in three genes (ATP1B1, RGS5, and SELE) were examined in relation to hypertension and blood pressure in a cohort of African-Americans. PMID: 21881522
• Interactions between the beta subunits of neighboring cells maintain the integrity of intercellular junctions. PMID: 21642423
• Na(+)-K(+) ATPase B1 can synergize with adriamycin and reverse drug resistance in MCF7 cells. PMID: 19664334
• Silencing of the ATP1B1 gene can enhance the proliferation and migration capability of SGC-7901 adenocarcinoma cells. PMID: 19619434
• Through its interaction with ATP1B1, MLC1 is involved in the control of intracellular osmotic conditions and volume regulation in astrocytes, providing new insights into the pathological mechanisms of MLC disease. PMID: 20926452
• Data indicate that CypB, through its interaction with Na/K-beta1, might regulate the maturation and trafficking of the pump through the secretory pathway. PMID: 21085665
• Research has identified that the beta1 subunit of the host Na(+)/K(+)-ATPase beta1 subunit (ATP1B1) interacts with the cytoplasmic domain of both the influenza A and B virus M2 and BM2 proteins. PMID: 21104370
• Data show that deglycosylation in polarized hepatic cells by drugs, or by site-directed mutagenesis of the N-linked-glycosylation residues, cause the Na+/K+-ATPase beta-subunit to traffic from the native basolateral to the apical/canalicular domain. PMID: 16339171
• Studies indicate a synergism between Sp1 and CREB in mediating regulation of Na-K ATPase beta1 subunit by PGRE3; while regulation occurring through PGRE1 also involves Sp1 and CREB. PMID: 16478973
• A study identified an interaction between Wolframin and Na+/K+ ATPase beta1 subunit in transfected Cos7 cells, and between endogenous proteins in placental, neuroblastoma, and MIN6 pancreatic beta-cell lines. PMID: 17947299
• E2A and Na/K-ATPase beta1 subunit expression in epithelial cells are regulated by interactions between these proteins. PMID: 18727914
• Reduced expression of the Na,K-beta(1) protein is associated with oxaliplatin resistance in cancer cells. PMID: 19322565
• It is proposed that kinase-dependent regulation of the Na(+)-K(+) pump occurs via glutathionylation of its beta(1) subunit (ATP1B1) at Cys46. PMID: 19542013
• ATP1B1 may confer susceptibility to BP regulation and hypertension in this Chinese population. PMID: 19563793
• Measured properties of the purified carboxy-terminal lobe suggest that the fragment is correctly folded and compatible with the proposed model of Na,K-ATPase beta1 subunit. PMID: 19694409
• Genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19305409

HGNC: 804

OMIM: 182330

KEGG: hsa:481

STRING: 9606.ENSP00000356789

UniGene: Hs.291196