ATP8A2 Antibody

AT8A2_HUMAN antibody; ATP antibody; Atp8a2 antibody; ATPase aminophospholipid transporter class I type 8A member 2 antibody; ATPase aminophospholipid transporter like class I type 8A member 2 antibody; ATPase class I type 8A member 2 antibody; ATPase phospholipid transporting 8A2 antibody; ATPIB antibody; CAMRQ4 antibody; EC=3.6.3.1 antibody; IB antibody; ML-1 antibody; ML1 antibody; P4 ATPase flippase complex alpha subunit ATP8A2 antibody; Probable phospholipid-transporting ATPase IB antibody

ATP8A2 is a catalytic component of a P4-ATPase flippase complex. This complex catalyzes the hydrolysis of ATP, which is coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes. This transport ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation is also implicated in vesicle formation and the uptake of lipid signaling molecules. When reconstituted into liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and, to a lesser extent, phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side towards the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may play a role in the regulation of neurite outgrowth. It is proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disc membranes and neuronal axon membranes. It may be involved in vesicle trafficking in neuronal cells. ATP8A2 is essential for normal visual and auditory function; it is involved in the survival of photoreceptor and inner ear spiral ganglion cells.