B4GALT1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (12-14 weeks)
Synonyms
B4GALT1 antibody; GALT antibody; GGTB2Beta-1,4-galactosyltransferase 1 antibody; Beta-1,4-GalTase 1 antibody; Beta4Gal-T1 antibody; b4Gal-T1 antibody; EC 2.4.1.- antibody; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase antibody; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase antibody; EC 2.4.1.38 antibody; Lactose synthase A protein antibody; EC 2.4.1.22 antibody; N-acetyllactosamine synthase antibody; EC 2.4.1.90 antibody; Nal synthase antibody; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 antibody; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] antibody
Target Names
B4GALT1
Uniprot No.
Target Background
Function
The Golgi complex form of B4GALT1 catalyzes the production of lactose in the lactating mammary gland. It is also implicated in the synthesis of complex-type N-linked oligosaccharides in numerous glycoproteins, as well as the carbohydrate moieties of glycolipids. The cell surface form of B4GALT1 functions as a recognition molecule during various cell-to-cell and cell-to-matrix interactions. These interactions are critical for processes such as development and egg fertilization, facilitated by the binding of specific oligosaccharide ligands on opposing cells or within the extracellular matrix. The secreted form of B4GALT1 is responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins and the carbohydrate moieties of glycolipids.
Gene References Into Functions
- Research suggests that engineering B4GALT1 to block cleavage and secretion could enhance its retention and function. To test this hypothesis, researchers replaced the CTS domains of bovine B4GALT1 with those from human FUT7, which is not cleaved and secreted. PMID: 25462875
- The beta4galt1 gene is potentially associated with milk production traits in dairy cows and warrants further investigation into its role in the genetics of milk production. PMID: 22311019
- The crystal structure of a mutant Met344His beta4Gal-T1, defined at 2.3 angstrom resolution, reveals that the N-acetylglucosamine residue at the nonreducing end of chitobiose forms extensive hydrophobic interactions with the highly conserved tyrosine-286 of beta4Gal-T1. PMID: 15449940
Database Links
Protein Families
Glycosyltransferase 7 family
Subcellular Location
[Isoform Long]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Cell projection, filopodium.; [Isoform Short]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Tissue Specificity
Detected in milk (at protein level).
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