BBX23 Antibody

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Description

Role of BBX23 in Plant Biology

BBX23 is a transcription factor that plays a crucial role in the regulation of plant growth in response to light. It is involved in a transcriptional cascade with other factors like PIF1/PIF3 and HY5 to control photomorphogenesis. BBX23 expression is inhibited by light, and its protein is degraded in darkness, indicating a complex regulatory mechanism .

Key Findings on BBX23 Function:

  • Light Response: BBX23 is involved in regulating hypocotyl elongation under different light conditions (red, far-red, blue).

  • Redundancy with BBX22: BBX23 has a redundant function with its homolog BBX22 in regulating hypocotyl growth.

  • Interaction with HY5: BBX23 physically interacts with HY5 to regulate light-responsive genes.

Structure and Function of Antibodies:

  • Composition: Antibodies consist of two heavy chains and two light chains, forming a "Y" shape with variable regions that determine antigen specificity .

  • Applications: Antibodies are used in various research techniques, including Western blotting, immunoprecipitation, and ELISA.

Bispecific Antibodies

While not directly related to BBX23, bispecific antibodies (BsAbs) are an area of active research in immunotherapy. BsAbs can bind two different antigens simultaneously, offering potential advantages in targeting complex diseases like cancer .

Characteristics of Bispecific Antibodies:

  • Dual Specificity: BsAbs can target two distinct epitopes or antigens.

  • Applications: Used in cancer immunotherapy to engage immune cells against tumor cells.

Data Table: Characteristics of Antibodies

FeatureDescription
StructureComposed of two heavy and two light chains.
SpecificityDetermined by variable regions of heavy and light chains.
ApplicationsUsed in Western blotting, immunoprecipitation, ELISA, etc.

Data Table: Bispecific Antibodies

FeatureDescription
Dual SpecificityCan bind two different antigens or epitopes.
ApplicationsPrimarily used in cancer immunotherapy.
ExamplesBlinatumomab, AMG 330.

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01 M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
14-16 week lead time (made-to-order)
Synonyms
BBX23 antibody; DBB4 antibody; STH6 antibody; At4g10240 antibody; F24G24.40 antibody; T9A4.2 antibody; B-box zinc finger protein 23 antibody; Protein DOUBLE B-BOX 4 antibody; Protein SALT TOLERANCE HOMOLOG 6 antibody
Target Names
BBX23
Uniprot No.

Target Background

Function
BBX23 is a putative transcription factor potentially involved in seedling photomorphogenesis.
Database Links

KEGG: ath:AT4G10240

STRING: 3702.AT4G10240.1

UniGene: At.33641

Subcellular Location
Nucleus.

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