BBX24 Antibody
Description
Introduction to BBX24
BBX24 is a transcriptional regulator in plants, notably in Arabidopsis, where it is involved in various physiological processes. It functions as a negative regulator of photomorphogenic UV-B responses and interacts with key proteins like COP1 and HY5 . Additionally, BBX24 is part of the ELF3-BBX24/BBX25-PIF4 module, which controls growth and development under different temperature conditions .
Role of BBX24 in Plant Biology
BBX24 is known for its role in regulating UV-B responses. It acts by interacting with COP1 and HY5, influencing hypocotyl elongation and anthocyanin biosynthesis under UV-B light . Furthermore, BBX24 is involved in the regulation of PIF4 activity by interacting with DELLA proteins, which are key components of the gibberellin signaling pathway .
Thermosensory Responses and BBX24
Recent studies have highlighted the involvement of BBX24 in thermosensory responses. The ELF3-BBX24/BBX25-PIF4 module plays a crucial role in controlling plant growth and development at different temperatures. BBX24 and BBX25 expression is enhanced at warm temperatures, contributing to increased PIF4 protein accumulation .
Expression Patterns of BBX24
BBX24 expression is influenced by temperature and circadian rhythms. At 27°C, BBX24 transcript levels are significantly higher than at 22°C, both at the end of the night and during the day . The protein levels of BBX24 also increase at 27°C compared to 22°C, particularly during the early part of the day (ZT2) .
Expression of BBX24 at Different Temperatures
| Temperature | Time of Day (ZT) | BBX24 Expression/Protein Level |
|---|---|---|
| 22°C | ZT0 | Hardly detectable |
| ZT2 | Peaks | |
| ZT4, ZT8 | Reduced | |
| 27°C | ZT0 | Hardly detectable |
| ZT2 | Elevated nearly two-fold | |
| ZT4, ZT8 | Comparable to 22°C |
Interaction with Other Proteins
BBX24 interacts with several key proteins:
Product Specs
Target Background
BBX24 (also known as STO) functions as a negative regulator of seedling photomorphogenesis and light-regulated hypocotyl elongation. It acts as a transcriptional corepressor of HY5, leading to downregulation of BBX22 expression. BBX24 exhibits additive effects with BBX25 (STH) during de-etiolation and the hypocotyl shade avoidance response. Furthermore, BBX24 negatively regulates photomorphogenic UV-B responses through interactions with COP1 and HY5. It may also function as a transcription factor in the salt stress response.
- BBX24 physically interacts with DELLA proteins, relieving DELLA-mediated repression of PIF4 activity. (PMID: 25656233)
- BBX24 expression is regulated by circadian rhythm and influenced by environmental factors and phytohormones. (PMID: 24498334)
- BBX24 and BBX25 interact with HYH, depleting HYH from its active pool and indirectly reducing HY5's photomorphogenesis-promoting function. (PMID: 23733077)
- BBX24 acts as a negative regulator of photomorphogenic UV-B responses by interacting with COP1 and HY5. (PMID: 22410790)
- BBX24 is localized to the nucleus. (PMID: 17605755)
