BET12 Antibody

Introduction to BET12

BET12 is a Qc-SNARE protein found in plants, particularly studied in Arabidopsis. It plays a crucial role in membrane trafficking, interacting with other SNARE proteins like MEMB12 to regulate cellular processes such as defense against pathogens .

Role of BET12 in Plant Defense

BET12 is involved in the regulation of plant defense mechanisms. It affects the trafficking of antimicrobial proteins like PR1, which is crucial for plant immunity against bacterial pathogens. While BET12 overexpression does not significantly alter resistance to bacterial infections, it impacts PR1 secretion, similar to MEMB12 .

BET12 Protein Structure and Localization

BET12 is an integral membrane protein with its N-terminus facing the cytosol. It localizes primarily to the Golgi apparatus and the trans-Golgi network (TGN) in plant cells. This localization is confirmed through confocal microscopy and immunogold electron microscopy .

Antibodies in Research

Antibodies are widely used in research for detecting and studying proteins. While there is no specific mention of a "BET12 Antibody," antibodies are crucial tools in protein localization studies, such as those involving BET12. For instance, anti-GFP antibodies are used to detect YFP-tagged BET12 in plant cells .

Data Table: Localization of YFP–BET12 in Plant Cells

This table summarizes the localization of YFP–BET12 in plant cells based on immunogold electron microscopy .

References:

1. Signal motif-dependent ER export of the Qc-SNARE BET12 interacts...
   Journal of Cell Science, 2018.

2. Efficacy and safety of bispecific antibodies therapy for relapsed or...
   Frontiers in Immunology, 2024.

3. Discovery and Optimization of Selective and In Vivo-Active Inhibitors of the Lyso-phosphatidylserine Lipase α/β-Hydrolase Domain-containing 12 (ABHD12)
   PMC, 2019.

4. Identification and Characterization of a Peptide That Specifically...
   PMC, 2001.

5. Phase 2 study of the bispecific T-cell engager (BiTE) antibody...
   PubMed, 2015.

6. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor
   PMC, 2017.

7. Identification and characterization of a peptide that specifically binds...
   PubMed, 2001.

8. Antibodies in late-stage clinical studies
   The Antibody Society, accessed 2023.

9. T-Bet Antibody (EP263) - Bio SB
   Bio SB, accessed 2023.