BIRC2 Antibody

Storage Buffer: PBS supplemented with 0.1% sodium azide, 50% glycerol, pH 7.3. Store at -20°C. Avoid freeze-thaw cycles.

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BIRC2

Q13490

The BIRC2 protein (also known as cIAP1) is a multifunctional protein with diverse regulatory roles. It influences caspase activity and apoptosis, modulates inflammatory signaling and immune responses, regulates mitogenic kinase signaling and cell proliferation, and impacts cell invasion and metastasis. Functioning as an E3 ubiquitin-protein ligase, it regulates NF-κB signaling, exhibiting both positive (canonical pathway) and negative (non-canonical pathway) effects. Its E3 ligase activity targets various proteins, including RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE, and MXD1/MAD1. cIAP1 also acts as an E3 ubiquitin ligase within the NEDD8 conjugation pathway, neddylating and inactivating effector caspases. It significantly regulates innate immune signaling through its interaction with pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLRs), and RIG-I-like receptors (RLRs). Crucially, cIAP1 protects cells from spontaneous ripoptosome formation (a caspase-dependent and -independent cell death mechanism) by ubiquitinating RIPK1 and CASP8. Furthermore, cIAP1 stimulates E2F1 transcriptional activity and plays a role in cell cycle modulation.

cIAP1's Role in Cellular Processes: Evidence from the Literature

1. A study highlights distinct biological consequences of inhibiting versus activating cIAP1 E3 ligase activity, suggesting potential therapeutic strategies for targeting c-MYC in cancer by modulating cIAP1 activity. PMID: 30181285
2. NAIP and cIAP expression patterns differ in polarized macrophages, suggesting a complex interplay in immune response. PMID: 29518103
3. DMBT1, CRNDE, and c-IAP1 interaction within the PI3K-AKT pathway is implicated in gallbladder cancer carcinogenesis. PMID: 27637083
4. cIAP1 regulates E2F1 stability and activity through non-degradative K63-polyubiquitination. PMID: 28542143
5. High cIAP1 expression correlates with colorectal cancer. PMID: 27014915
6. Cytoplasmic RARγ regulates RIP1-initiated cell death when cIAP activity is inhibited. PMID: 28871172
7. High cIAP1 expression is associated with lung tumorigenesis. PMID: 27197231
8. Molluscum contagiosum virus MC159 may competitively bind NEMO, preventing cIAP1-induced NEMO polyubiquitination. PMID: 28515292
9. Baseline TNFα expression correlates with sensitivity to IAP antagonists. PMID: 27608596
10. cIAP1-induced mitophagy leads to dysfunctional mitochondria and reduced ATP levels; cIAP1 ubiquitination is a critical regulator of this process. PMID: 27693792
11. Overexpression of cIAP1 is associated with glioma. PMID: 26666816
12. High cIAP1 expression is associated with triple-negative breast cancer. PMID: 26733177
13. cIAP1/2 mediate BCL10 ubiquitination, essential for BCR-dependent NF-κB activity in DLBCL. PMID: 27070702
14. AZD5582 induces apoptosis through Mcl-1 downregulation by targeting cIAP1 and XIAP in pancreatic cancer. PMID: 26314849
15. Smac/DIABLO shows an inverse correlation with XIAP, cIAP-1, and cIAP-2. PMID: 25549803
16. IRF-1 reduces NF-κB activity and suppresses TRAF2 and cIAP1 expression in breast cancer cells. PMID: 26011589
17. cIAP1 is associated with tumor progression in human ovarian cancer. PMID: 26168135
18. XIAP and cIAP1 activate NF-κB signaling, leading to Beclin 1 transcriptional activation and autophagy induction. PMID: 25669656
19. cIAP1 and cIAP2 are potential therapeutic targets for preventing preterm birth. PMID: 25046208
20. A20 downregulates cIAP1/2. PMID: 25911380
21. GDC-0152 induces apoptosis in human leukemia through caspase-dependent mechanisms involving IAP downregulation and PI3K/Akt inhibition. PMID: 25273171
22. IGF2BP1 is a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma. PMID: 24704827
23. Survivin affects cIAP1 stability, influencing cell sensitivity to YM155. PMID: 25635055
24. cIAP1 and cIAP2 expression is increased in placenta from women with pre-existing maternal obesity and in response to pro-inflammatory cytokines. PMID: 25113061
25. XIAP, cIAP1, and cIAP2 are critical regulators of cell death and survival, representing attractive cancer therapy targets. PMID: 24841289
26. cIAP1 undergoes a conformational change during activation due to the dynamic nature of its closed form. PMID: 25383668, PMID: 25469840
27. cIAP1 is involved in pancreatic beta cell survival during endoplasmic reticulum stress. PMID: 24559922
28. cIAP1 regulates TNF-induced actin cytoskeleton reorganization through a cdc42-dependent pathway. PMID: 24276241
29. ARC is regulated via BIRC2/MAP3K14 signaling and functions as a resistance factor to birinapant-induced leukemia cell death. PMID: 25079338
30. EndoG interacts with cIAP1; IAPs ubiquitinate EndoG via K63 linkages without affecting EndoG levels, suggesting a regulatory role independent of degradation. PMID: 25139236
31. cIAPs downregulate PACS-2, restraining TRAIL-induced killing of liver cancer cells. PMID: 24633224
32. Selenite causes CYLD upregulation and cIAP downregulation, contributing to RIP1 degradation and apoptosis in colorectal tumor cells. PMID: 24577083
33. XIAP and cIAP1 regulate the MEKK2/3-MEK5-ERK5 signaling module, influencing muscle cell differentiation. PMID: 24975362
34. Higher cIAP1 expression is observed in ovarian endometriomas. PMID: 24382102
35. Compounds sensitizing cancer cells to TRAIL effectively bind to XIAP and induce cIAP-1 and cIAP-2 degradation. PMID: 24194568
36. Ceramide analogs sensitize metastatic colon and breast cancers to apoptosis, suppressing metastasis in vivo. PMID: 24422988
37. Silencing of IAPs reduces TRAP-evoked RhoA activation. PMID: 24371121
38. Cisplatin triggers proteasomal degradation of c-IAP1, c-IAP2, and XIAP in a ROS-dependent manner. PMID: 24425875
39. Discovery of benzodiazepinone 36, a selective XIAP BIR2 inhibitor. PMID: 24093940
40. A potent BIR2-selective inhibitor with in vivo pharmacokinetic properties potentiates apoptotic signaling. PMID: 24083782
41. Palmitate does not decrease cIAP-1 and cIAP-2 mRNA expression. PMID: 24008361
42. cIAP1 expression is decreased by Foxa2 silencing and increased by Foxa2 overexpression. PMID: 23275033
43. BIRC2 and BIRC3 regulate JNK signaling, NF-κB, and fine-tune transcriptional responses. PMID: 23250032
44. IAP antagonist-based cancer treatment may be compromised by osteoporosis. PMID: 23269702
45. The BIRC2 3'UTR contains a cis-acting element affecting mRNA stability and protein expression. PMID: 23605047
46. OTUB1 regulates NF-κB and MAPK signaling and TNF-dependent cell death by modulating c-IAP1 stability. PMID: 23524849
47. A molecular mechanism for cIAP1 regulation in the NOD2 signaling pathway is described. PMID: 23109427
48. c-IAP1 acts on PCSK9 secretion and lysosomal localization. PMID: 23085658
49. IAP inhibitors and lexatumumab synergistically trigger apoptosis in RMS cells. PMID: 22927431

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HGNC: 590

OMIM: 601712

KEGG: hsa:329

STRING: 9606.ENSP00000227758

UniGene: Hs.696238

IAP family

Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.