BIRC3 Antibody

1. Elevated BIRC3 expression has been linked to Oral squamous cell carcinoma. PMID: 29286141
2. Research indicates that Pellino-1 contributes to lung oncogenesis by upregulating inhibitor of apoptosis protein 2 (cIAP2), promoting cell survival and chemoresistance. PMID: 27248820
3. BIRC3 plays a unique role in facilitating the progression of glioma from low- to high-grade tumors. PMID: 27074575
4. cIAP2 expression was found to be elevated in human gallbladder cancer tissues. PMID: 28295868
5. Destabilization of TRAF2 by miR-17 reduced the ability of TRAF2 to associate with cIAP2, resulting in downregulation of TNF-α-induced NF-κBp65, c-Jun, and STAT3 nuclear translocation and the production of IL-6, IL-8, MMP-1, and MMP-13 in human rheumatoid arthritis synovial fibroblasts. PMID: 27534557
6. The expression of cIAP2 mRNA was significantly higher in groups with Helicobacter pylori infection, atrophic gastritis/intestinal metaplasia, and Helicobacter pylori-positive early gastric cancer compared to control groups. PMID: 27282269
7. Polymorphisms in the BIRC3 gene have been associated with a protective effect against asthma susceptibility and a reduced inflammatory cell load. PMID: 27304223
8. Studies suggest that miR-34a can inhibit tumor invasion and metastasis in osteosarcoma, potentially by downregulating the expression of C-IAP2 and Bcl-2 protein. PMID: 28635396
9. Research demonstrates that BIRC3 expression increases following the acquisition of resistance to temozolomide (TMZ) and irradiation in glioblastoma. PMID: 26888114
10. High BIRC3 expression has been linked to pancreatic cancer. PMID: 26815504
11. Network analysis identified BIRC3 as a pathogenic gene in childhood asthma. PMID: 27420950
12. The clinical impact of small subclones harboring NOTCH1, SF3B1, or BIRC3 mutations in chronic lymphocytic leukemia patients appears less pronounced than that of small TP53 mutated subclones. PMID: 26819056
13. cIAP2 is upregulated in regenerative epithelial cells both in ulcerative colitis and experimental intestinal wounds. Inhibition of cIAP2 decreases wound healing in vitro, potentially through inhibition of migration. [review] PMID: 26513451
14. LapR cells exhibited increased levels of two inhibitors of apoptosis (IAPs), survivin and c-IAP-2, which are known to block caspase activation downstream of cytosolic cytochrome C release. PMID: 25692408
15. API2-MALT1 induces paracaspase-mediated cleavage of the tumor suppressor protein LIMA1. PMID: 25569716
16. This study identifies BIRC3 as a potential predictive marker for discriminating patients with esophageal and esophagogastric junction adenocarcinoma who might benefit from preoperative chemoradiotherapy. PMID: 26291056
17. Research indicates that Neisseria gonorrhoeae stimulation of human endocervical epithelial cells induces the release of cIAP2, a crucial regulator of cell death and immune signaling. PMID: 26077759
18. Cytoplasmic expression of HuR is associated with cIAP2 expression in Oral Squamous Cell Carcinomas (OSCCs). PMID: 23852810
19. In patients with 11q-deleted chronic lymphocytic leukemia treated with first-line chemotherapy, ATM mutation, rather than BIRC3 deletion or mutation, identifies a subgroup with a poorer prognosis. PMID: 24584352
20. A number of genes not previously known to be affected by RUNX2 expression, including BIRC3, genes encoded on the mitochondrial genome, and several genes involved in bone and tooth formation, have been identified. PMID: 24349465
21. TNF-α induced apoptosis of gastric cancer cells via accelerated degradation of inhibitor of apoptosis family members, CIAP2, XIAP, and survivin. PMID: 25513960
22. cIAP2 is a regulator of human intestinal wound healing through enhanced migration along with activation of Rac1. PMID: 25394657
23. Data suggests that tumor necrosis factor inducible protein A20-mediated inhibitor of apoptosis protein-2 (cIAP-2) is important in endothelial cell resistance to tumor necrosis factor alpha (TNF-α)-induced apoptosis. PMID: 24595242
24. Identification and function of the NIK IAP binding motif, which promotes c-IAP1-dependent ubiquitylation of NIK, have been established. PMID: 25246529
25. A distinctive role of c-IAP2 as a stabilizer of XIAP, likely involved in the regulation of NFκB activation and apoptosis in GBM cells, has been determined. PMID: 24552816
26. Increased expression of BIRC3 has been observed with the progression of chronic myeloid leukemia. PMID: 24266799
27. Research implicates RIP1 ubiquitination as a critical component of API2-MALT1-dependent lymphomagenesis. PMID: 23770847
28. BIRC3 gene mutation has been associated with chronic lymphocytic leukemia. PMID: 23558524
29. cIAP-2 has been identified as a novel inducer of platinum resistance in ovarian carcinoma cells, suggesting an axis starting with an encounter between cisplatin and these cells, mediated sequentially by IL-6 and cIAP-2, resulting in cisplatin resistance. PMID: 23052480
30. The expression of C-IAP2 in hepatocellular carcinoma is associated with tumor recurrence and metastasis. PMID: 22820591
31. Clonal evolution from lower to higher risk in chronic lymphocytic leukemia implicated the emergence of NOTCH1, SF3B1, and BIRC3 abnormalities in addition to TP53 and 11q22-q23 lesions. PMID: 23243274
32. A novel role for cIAP2 in maintaining wild-type p53 levels by preventing both an NFκB-mediated increase and IKKα/-β-dependent transcriptional and post-translational modifications of MDM2 has been observed. PMID: 23032264
33. Studies show that the API2-MALT1 fusion oncoprotein induces proteolytic cleavage of NF-κB-inducing kinase (NIK). The resulting deregulated NIK activity is associated with constitutive noncanonical NF-κB signaling, enhanced B cell adhesion, and apoptosis resistance. PMID: 21273489
34. TRAF2 and cIAP2 are involved in TWEAK-induced MMP-9 production in fibroblast-like synoviocytes in rheumatoid arthritis. PMID: 21229359
35. NF-κappaB, acting through two response elements, is required for estrogen receptor recruitment to an adjacent estrogen response element in the BIRC3 promoter. PMID: 22083956
36. BIRC3 disruption is a common mechanism across marginal zone B-cell lymphomagenesis. PMID: 21881048
37. Findings suggest that CpG-induced protection may be mediated by c-IAP-2 through the calcium-activated JNK pathway. PMID: 22068233
38. cIAP2 may play a significant role in Helicobacter pylori-induced gastric carcinogenesis. PMID: 21963223
39. Research confirms that mRNA and protein levels for cIAP2 are highly upregulated in breast cancer cells by E2 and cytokines. PMID: 21152357
40. These data reveal a novel mechanism for the inhibition of hepatitis B virus replication by cIAP2 via acceleration of the ubiquitin-proteasome-mediated decay of polymerase. PMID: 21865390
41. The API2-MALT1 fusion gene is a distinctive genetic aberration in MALT lymphomas and is not present in diffuse large B cell lymphoma. PMID: 20079017
42. Adenosine downregulated the expression of mRNAs and proteins for Bcl-X(L) and inhibitor of apoptosis protein 2 (IAP2) to directly inhibit caspase-3, -7, and -9, but upregulated the expression of mRNA and protein for DIABLO, an inhibitor of IAPs. PMID: 20063052
43. Arsenic trioxide suppresses transcription of cIAP2 mRNA in NB-4 cells. PMID: 19763917
44. These results support a role for Tax-dependent cIAP-2 expression in preventing the death of naturally infected CD8(+) cells and thereby in their clonal expansion in vivo. PMID: 20863547
45. TTP can bind to the 2nd AU-rich elements of cIAP2 mRNA 3'UTR and destabilize cIAP2 mRNA by forming complexes with Dcp2 and Xrn1. PMID: 20691152
46. Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells. PMID: 20576118
47. Cancer cell lines evade Smac mimetic-induced apoptosis by upregulating cIAP2, which, although initially degraded, rebounds. cIAP2 is induced by TNFα via NF-κB, and modulation of the NF-κB signal renders cells sensitive to Smac mimetics. PMID: 20547836
48. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes; biochemical, structural, and cell biological studies on the interaction between TRAF2 and cIAP2 and on the ability of TRAF1 to modulate this interaction. PMID: 20385093
49. Results provide the first structures of BIR domains from human NAIP and cIAP2. PMID: 19923725
50. REVIEW: Genetic alterations involving API2 underlying the pathogenesis of MALT lymphoma. PMID: 11960389

Show More

Hide All

HGNC: 591

OMIM: 601721

KEGG: hsa:330

STRING: 9606.ENSP00000263464

UniGene: Hs.127799