BMP 2 Antibody
Description
Research Applications
Clinical and Therapeutic Applications
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Bone Regeneration: Anti-BMP-2 monoclonal antibodies immobilized on scaffolds (e.g., titanium, alginate) enhance endogenous BMP-2 capture, promoting bone repair in rodent models .
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Osteoporosis Treatment: Systemic administration of recombinant human BMP-2 (rhBMP-2) reverses bone loss in mice by activating mesenchymal stem cells .
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Spinal Fusion: rhBMP-2 antibodies are used to monitor immunogenicity in patients, with transient antibody rates (0.8–6.4%) showing no clinical sequelae .
In Vitro and Preclinical Studies
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Stem Cell Differentiation: BMP-2 antibodies validate BMP-2’s role in embryonic and mesenchymal stem cell differentiation into osteoblasts .
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Synovial Cell Effects:
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Antibody Kinetics: Fluorescently labeled BMP-2 (DyLight) retains bioactivity, enabling real-time tracking of cellular uptake .
Clinical Immunogenicity
Challenges and Considerations
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Cross-Reactivity: Some antibodies cross-react with BMP-4 and BMP-7, necessitating validation .
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Storage Stability: Requires storage at -20°C or 2–8°C with avoidance of freeze-thaw cycles .
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Clinical Safety: Low immunogenicity and transient antibody responses minimize risks in therapeutic applications .
Future Directions
Product Specs
Product Science Overview
Bone Morphogenetic Protein-2 (BMP-2) is a member of the Transforming Growth Factor-Beta (TGF-β) superfamily, which plays a crucial role in various developmental processes, including bone and cartilage formation, embryogenesis, and tissue homeostasis . BMP-2 is particularly significant in the context of bone remodeling and repair, making it a key focus in both basic and clinical research.
BMP-2 is a multi-functional growth factor that is essential for the differentiation of mesenchymal cells into osteoblasts, which are responsible for bone formation . It activates osteogenic genes such as Runt-Related Transcription Factor 2 (RUNX2) and promotes the expression of other bone-related proteins . BMP-2 also plays a role in adipogenesis, influencing the development of adipose tissue in a depot-specific manner .
Recombinant human BMP-2 (rhBMP-2) has been approved by the Food and Drug Administration (FDA) for use in spinal fusion surgery, tibial shaft repair, and maxillary sinus reconstructive surgery . Despite its therapeutic potential, the use of rhBMP-2 has been associated with several adverse effects, prompting the development of alternative treatments .
The mouse anti-human BMP-2 antibody is a monoclonal antibody designed to specifically bind to human BMP-2. This antibody is commonly used in research to study BMP-2’s role in various biological processes and to investigate its potential therapeutic applications. The antibody can neutralize BMP-2 activity, making it a valuable tool for understanding BMP-2 signaling pathways and its effects on cell differentiation and proliferation .
Recent studies have highlighted the role of BMP-2 in regulating adipogenesis and its depot-specific effects on adipose tissue development . BMP-2 has been shown to promote adipogenesis in abdominal preadipocytes, indicating its potential role in regional fat distribution . Additionally, BMP-2 signaling through the SMAD1/5/8 pathway has been implicated in various cellular processes, including proliferation, differentiation, and apoptosis .
