BMP5 Antibody
Description
Introduction
Bone Morphogenetic Protein 5 (BMP5) is a member of the Transforming Growth Factor-beta (TGF-β) superfamily, known for its role in regulating bone and cartilage development, as well as its involvement in cancer progression and ocular diseases . The BMP5 antibody is a critical tool for detecting and studying this protein in biological systems. This article synthesizes data on the antibody’s properties, applications, and its role in advancing medical research.
Key Properties of BMP5 Antibody
The BMP5 antibody is a monoclonal immunoglobulin designed to specifically bind to the BMP5 protein. Two prominent commercial variants are:
Both antibodies are validated for their specificity and utility in detecting BMP5 in tissue lysates and cell extracts.
Applications in Research and Diagnostics
The BMP5 antibody is employed in:
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Western Blotting: To quantify BMP5 expression in lung, liver, and optic nerve tissues .
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ELISA: For measuring BMP5 levels in biological fluids (e.g., serum, CSF) .
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Immunohistochemistry: To localize BMP5 in tumor microenvironments, particularly in lung adenocarcinoma .
Lung Adenocarcinoma Prognosis
Studies using BMP5 antibodies reveal that low BMP5 expression correlates with poor prognosis in lung adenocarcinoma patients. A retrospective analysis of 93 cases found:
Cardioprotective Effects
In ischemic cardiomyopathy models, BMP5 antibodies demonstrated that BMP5 upregulation protects cardiomyocytes during hypoxia. Knockdown of BMP5 abolished this protective effect, underscoring its therapeutic potential .
Product Specs
Target Background
- Research suggests a significant role of the miR-32/BMP5 axis in the development of colorectal cancer. PMID: 30119170
- Studies have indicated that BMP5 might serve as a potential prognostic biomarker or therapeutic target for patients with non-small cell lung cancer (NSCLC). PMID: 25994008
- Analysis revealed that the ASPN rs13301537 T to C change and variant C genotype may contribute to the risk of knee osteoarthritis in a Chinese Han population. PMID: 25030405
- Data indicate a significant association between the bone morphogenetic protein 5 (BMP5) microsatellite and knee osteoarthritis (OA) in women, but not in men. PMID: 23186552
- BMP5 is elevated in the stenotic colon segment of Hirschsprung disease patients, suggesting a potential role of BMP5 signaling in disease development. PMID: 24551273
- BMP5 and BMP7 are implicated in cardiomyocyte differentiation defects. PMID: 24384427
- Genetic variations in CASP3 rs4862396, BMP5 rs3734444, and IRS2 rs7986346 may influence survival outcomes in patients receiving androgen-deprivation therapy for prostate cancer. PMID: 22844442
- BMP-5 is expressed in the tubules of adult kidneys. Its reduced expression in nephrosclerosis and its regenerative capabilities in HK-2 cells suggest a protective role in hypertensive nephrosclerosis. PMID: 21319131
- BMP4 and BMP5 collectively inhibit the growth and promote migration and invasion of pancreatic cells, highlighting their biphasic role in pancreatic cancer progression. PMID: 21704030
- Variations in BMP5 gene expression may contribute to the genetic susceptibility to osteoarthritis. PMID: 20021689
- BMP-5 mRNA expression levels are relatively lower in malignant schwannomas compared to benign lesions. PMID: 11642720
- BMP-5 stimulates the production of osteopontin, BMP-2, alkaline phosphatase, and core binding factor alpha 1 mRNAs in human periodontal ligament cells. PMID: 15516325
- BMP5 is expressed in normal synovial tissue and is downregulated in osteoarthritis and rheumatoid arthritis. PMID: 16542506
- Studies have examined the differential allelic expression (DAE) of BMP5 in human mesenchymal tissues obtained from individuals undergoing joint replacement for osteoarthritis treatment. PMID: 17220169
