BMPR1B Antibody, Biotin conjugated

1. Research has identified the tumor-suppressive BMPR1B regulated by miR-1274a in clear cell renal cell carcinoma. PMID: 29192325
2. We detected two BMPR1B mutations in two unrelated PRS families, suggesting that disruption of BMPR1B is likely a cause of human PRS. PMID: 28418932
3. Over-expression of CYP2J2 in MDA-MB-468-derived breast cancer cells activates BMPR1B expression, potentially contributing to increased migration. PMID: 27720933
4. Mutations in three genes (GDF5, NPR2, BMPR1B) have been reported to cause different forms of acromesomelic dysplasia. PMID: 26926249
5. Findings demonstrate an association between age-induced depletion of the ovarian reserve and BMPR1B receptor density, suggesting that dysregulation of BMP receptor signaling might inhibit the normal steroidogenic differentiation required for maturation in older patients. PMID: 26805635
6. Low expression of BMPR1B has been linked to breast cancer. PMID: 26684357
7. Two novel mutations in BMPR1B were identified in two patients with brachydactyly type A1. PMID: 25758993
8. Utilizing computational analyses with the COREX/BEST algorithm, the study revealed an overall pattern connecting various regions of the BMPR-1B ectodomain, including the four conserved residues within the protein-protein interface. PMID: 26562759
9. A novel mutation in the BMPR1B gene (R486L) was identified in a Polish family, further defining the phenotypic features associated with BMPR1B-related brachydactyly. PMID: 25776145
10. Data suggests that a hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia. PMID: 26105076
11. Imbalance in BMP2 levels within the breast stem cell niche initiates epithelial transformation by excessively amplifying the BMPR1B cell response. PMID: 25601208
12. Disrupting the binding of miR-125b to BMPR1B would increase protein expression, reducing abnormal cell proliferation as well as serum and cellular CA125 levels. PMID: 24339876
13. Data indicates missense (c.157T>C, p.(C53R)) or nonsense (c.657G>A, p.(W219*)) mutations in bone morphogenetic protein receptor type IB (BMPR1B) in two consanguineous families with acromesomelic chondrodysplasia-type Grebe. PMID: 24129431
14. Shear-induced apoptosis and autophagy are mediated by bone morphogenetic protein receptor type (BMPR)-IB, BMPR-specific Smad1 and Smad5, and p38 mitogen-activated protein kinase. PMID: 24021264
15. A significant association was observed between the 455C allele of BMP4 and increased left ventricular internal diameter systolic (p=0.004) and between 1650T allele of BMPR1B and lower left atrium diameter (p=0.038). PMID: 22971142
16. The study suggests that BMPR1B mutations are associated with the pathogenesis of childhood idiopathic pulmonary arterial hypertension. PMID: 22374147
17. BMP15 preferentially uses BMPR1B as its type I receptor, implying a crucial role for the BMPR1B receptor in human female fertility. PMID: 22294741
18. rs1434536 in the 3'UTR of BMPR1B gene influences the binding capacity of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer, particularly in patients aged>70 years. PMID: 21556765
19. BMPR1B has been detected in the human retina and retinoblastoma cell lines. PMID: 21152263
20. Linkage analysis in brachydactyly (BD) type A2 mapped a locus for BD type A2 to 4q21-q25. This region includes the gene bone morphogenetic protein receptor 1B. PMID: 14523231
21. BMP-2-induced apoptosis was mediated by BMP-RIB in osteoblasts and occurred independently of BMP-2-induced osteoblast differentiation. PMID: 14576167
22. The BMP system is strongly involved in pulmonary artery smooth muscle mitosis through ALK-6, contributing to the progression of vascular remodeling of pulmonary arteries in pulmonary hypertension. PMID: 15192043
23. Anti-Mullerian hormone is a gonadal tumor suppressor that mediates its effects through a specific type II receptor and the bone morphogenetic protein (BMP)-specific Smad proteins. PMID: 15897891
24. GDF5 is a novel brachydactyly type A2 causing gene involving impaired BMPR1b activity. PMID: 16014698
25. Results indicate that increased bone morphogenetic protein receptor (BMPR)-IB by TGF-beta1, FGF-2, and PDGF-AB significantly enhances BMP-2-induced osteogenesis in vitro. PMID: 17001689
26. HGF up-regulates the expression of the bone morphogenetic protein receptors, BMPR-IB and BMPR-II, in prostate cancer cells. PMID: 17203235
27. A significant shift in the emission maximum from 498 to 510 nm was detected when bis-ANS binds ecBMPR-IB. FRET revealed close proximity between the tyrosine and bis-ANS binding site. PMID: 17363346
28. Our findings suggested the potential involvement of ALK6 activation by rhTGFbetas in the synergy between rhTGFbetas and rhBMPs. PMID: 17381068
29. There was significant down-regulation of ALK-6 (activin receptor-like kinase 6) expression in asthma patients at baseline; allergy challenge was associated with upregulation. PMID: 18292470
30. Changes in BMPR1B localization regulate osteogenic responses of bone cells to BMP2. PMID: 18619554
31. The interaction of Ror2 with BRIb is specific and independent of post-translational N-glycosylation. PMID: 19135982
32. Decreased expression of BMPR-IB correlates with poor prognosis in breast cancer patients and leads to increased cell proliferation of breast cancer cells in vitro. PMID: 19451094
33. Decrease in BMPR-1B expression resulted in decreased SMAD1 phosphorylation and correlated with the malignant grade of human gliomas and a poor prognosis. PMID: 19513897
34. Results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk in breast cancer. PMID: 19738052

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HGNC: 1077

OMIM: 112600

KEGG: hsa:658

STRING: 9606.ENSP00000264568

UniGene: Hs.598475