HUA1 Antibody
Description
Overview of Influenza-Targeting Antibodies
Antibodies against influenza viruses primarily target hemagglutinin (HA) or neuraminidase (NA) surface proteins. These antibodies are categorized by their binding regions and functional mechanisms:
HA Stalk-Specific Antibodies
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6F12 Antibody: Neutralizes H1 viruses spanning 79 years of antigenic drift. Prevents weight loss in mice at low doses (0.3–0.9 mg/kg) and binds the HA stalk via a conformational epitope .
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CR6261: Targets group 1 HAs (H1, H5) and protects against lethal H1N1 challenge in mice .
HA Head-Specific Antibodies
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KPF1: Binds a conserved epitope on the H1 HA globular head, neutralizing 83% of tested H1 isolates (including 1918 H1N1). In vivo efficacy includes 100% survival in prophylactic mouse models .
Neuraminidase-Targeting Antibodies
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FNI9: Inhibits NA activity across all group 1 and 2 IAVs. Prophylactic administration (0.3 mg/kg) fully protects mice from H1N1 challenge without requiring Fc-mediated effector functions .
Functional Comparisons
Clinical Implications
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HA Stalk Antibodies: Associated with reduced viral shedding in human challenge studies but do not independently predict disease severity .
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HA Head Antibodies: Potent neutralizers but limited to specific subtypes (e.g., H1) due to antigenic drift .
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NA Antibodies: Synergize with HA-targeting antibodies; FNI9’s Fc-independent activity suggests therapeutic potential even in late-stage infection .
Product Specs
Components: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Target Background
HUA1 is involved in flower development. It functions in floral reproductive organ identity determination by binding to and promoting the processing of AGAMOUS (AG) pre-messenger RNA (pre-mRNA). This activity occurs in association with HUA2 and HEN4 proteins.
