CYP94C1 Antibody

This antibody targets CYP94C1, an enzyme involved in the oxidation of jasmonoyl-L-isoleucine (JA-Ile), a crucial bioactive phytohormone within the jasmonate-mediated signaling pathway. Specifically, CYP94C1 catalyzes the conversion of 12-hydroxy-JA-Ile (12OH-JA-Ile) to its carboxy-derivative, 12COOH-JA-Ile. This activity exerts negative feedback control on JA-Ile levels, thereby modulating jasmonate responses. Furthermore, CYP94C1 demonstrates in vitro activity as an in-chain fatty acid hydroxylase, catalyzing the hydroxylation of 12-hydroxy-jasmonoyl-L-phenylalanine (12OH-JA-Phe) to its carboxy-derivative, 12COOH-JA-Phe.

• Studies using double and triple knockout mutants of CYP94B1, CYP94B3, and CYP94C1 demonstrated that these mutations blocked oxidation steps, resulting in a 3- to 4-fold increase in JA-Ile accumulation in wounded leaves compared to wild-type levels. (PMID: 26968098)
• CYP94B3 and CYP94C1 are implicated in the production of oxidized derivatives of jasmonoyl-phenylalanine and jasmonoyl-isoleucine in response to wounding. (PMID: 26164240)
• Research findings highlight the dual role of CYP94B3/C1 in antimicrobial defense. (PMID: 25903915)
• These results establish CYP94B3/C1-mediated oxidation as a primary catabolic pathway for JA-Ile hormone turnover. (PMID: 22215670)

KEGG: ath:AT2G27690

STRING: 3702.AT2G27690.1

UniGene: At.13273