CAT3 Antibody
Description
Introduction to CAT3 Antibody
The CAT3 antibody targets the Cationic Amino Acid Transporter 3 (CAT3), also known as SLC7A3. This protein is part of the solute carrier family 7 and functions as a sodium-independent cationic amino acid transporter. It plays a crucial role in mediating the uptake of cationic amino acids such as arginine, lysine, and ornithine .
Characteristics of CAT3 Antibody
The CAT3 antibody is typically a polyclonal rabbit IgG antibody, designed for specific applications like Western blotting. It is available in various formulations, such as lyophilized or BSA-free solutions, depending on the supplier.
Key Features of CAT3 Antibodies:
| Feature | Description |
|---|---|
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic peptides corresponding to specific regions of SLC7A3 |
| Applications | Western Blot (WB) |
| Reactive Species | Human (for specific antibodies like A09720-3), Mouse (for NBP1-74144) |
Research Findings and Applications
Research on CAT3 antibodies primarily focuses on their use in studying the function and expression of SLC7A3 in various tissues. These antibodies are crucial for detecting SLC7A3 in cell lysates and tissues, aiding in understanding its role in physiological and pathological processes.
Western Blot Analysis:
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Antibody A09720-3: This antibody is validated for Western blot applications and reacts specifically with human SLC7A3. It is used at concentrations of 0.25-0.5 μg/mL for optimal results .
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Antibody NBP1-74144: This BSA-free antibody is validated for mouse samples and is used at a concentration of 1.0 μg/mL for Western blotting .
Potential Therapeutic Targets:
While CAT3 itself is not directly targeted for therapeutic interventions, research on related cationic amino acid transporters (like CAT1) suggests potential applications in cancer therapy. Monoclonal antibodies against CAT1 have shown antitumor effects by inhibiting cell growth in colorectal cancer models .
